Cysteine desulfurase
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Cysteine desulfurase'''<ref>PMID:21638687</ref> == Disease == ==...) |
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| - | + | <StructureSection load='5j8q' size='340' side='right' caption='Caption for this structure' scene=''> | |
| - | <StructureSection load=' | + | |
== Function == | == Function == | ||
| - | '''Cysteine desulfurase'''<ref>PMID: | + | '''Cysteine desulfurase''' (SUFS) catalyzes the conversion of L-cysteine to L-alanine and sulfane sulfur. SUFS has a role in the biosynthesis of Fe-S custers, thiamine, thionucleosides, biotin, lipoic acid, molybdopterin and NAD<ref>PMID:12382038</ref>. SUFS is a PLP-dependent enzyme. |
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
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| + | The structure | ||
</StructureSection> | </StructureSection> | ||
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**[[5b7s]] - ToSUFS + PLP derivative - ''Thermococcus onnurineus''<br /> | **[[5b7s]] - ToSUFS + PLP derivative - ''Thermococcus onnurineus''<br /> | ||
**[[5ft4]], [[4lw2]], [[4lw4]], [[1p3w]], [[3lvm]] - EcSUFS IscS + PLP - ''Escherichia coli''<br /> | **[[5ft4]], [[4lw2]], [[4lw4]], [[1p3w]], [[3lvm]] - EcSUFS IscS + PLP - ''Escherichia coli''<br /> | ||
| - | **[[3lvj]], [[3lvk]] - EcSUFS + tusA + PLP <br /> | + | **[[3lvj]], [[3lvk]] - EcSUFS IscS + tusA + PLP <br /> |
| - | **[[3lvl]] - EcSUFS + NifU-like protein + PLP <br /> | + | **[[3lvl]] - EcSUFS IscS + NifU-like protein + PLP <br /> |
**[[6c9e]] - SUFS + PLP derivative - ''Legionella pneumophila''<br /> | **[[6c9e]] - SUFS + PLP derivative - ''Legionella pneumophila''<br /> | ||
**[[5wt2]] - HpSUFS IscS + PLP<br /> | **[[5wt2]] - HpSUFS IscS + PLP<br /> | ||
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**[[5b7u]] - ToSUFS + mercaptocysteine + PLP derivative + cysteine<br /> | **[[5b7u]] - ToSUFS + mercaptocysteine + PLP derivative + cysteine<br /> | ||
**[[5b87]], [[5b89]] - ToSUFS + mercaptocysteine + PLP + alanine<br /> | **[[5b87]], [[5b89]] - ToSUFS + mercaptocysteine + PLP + alanine<br /> | ||
| - | **[[5ft5]] - EcSUFS + mercaptocysteine + PLP <br /> | + | **[[5ft5]] - EcSUFS CsdA + mercaptocysteine + PLP <br /> |
| - | **[[5ft6]] - EcSUFS + cysteine sulfonic acid + PLP <br /> | + | **[[5ft6]] - EcSUFS CsdA + cysteine sulfonic acid + PLP <br /> |
| - | **[[5ft8]] - EcSUFS + sulfur acceptor protein + mercaptocysteine + PLP <br /> | + | **[[5ft8]] - EcSUFS CsdA + sulfur acceptor protein + mercaptocysteine + PLP <br /> |
**[[5db5]] - EcSUFS + mercaptocysteine + PLP + cysteine<br /> | **[[5db5]] - EcSUFS + mercaptocysteine + PLP + cysteine<br /> | ||
**[[5wt4]] - HpSUFS IscS (mutant) + PLP derivative + cysteine derivative - ''Helicobacter pylori''<br /> | **[[5wt4]] - HpSUFS IscS (mutant) + PLP derivative + cysteine derivative - ''Helicobacter pylori''<br /> | ||
Revision as of 10:59, 5 November 2018
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3D structures of cysteine desulfurase
Updated on 05-November-2018
References
- ↑ Mihara H, Esaki N. Bacterial cysteine desulfurases: their function and mechanisms. Appl Microbiol Biotechnol. 2002 Oct;60(1-2):12-23. doi:, 10.1007/s00253-002-1107-4. Epub 2002 Sep 4. PMID:12382038 doi:http://dx.doi.org/10.1007/s00253-002-1107-4
