Sandbox Reserved 1473

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'''FUNCTIONS'''
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G-Protein Coupled Receptors (GPCR), also known as 7 transmembrane (7TM) proteins [because of its 7 constituent alpha helices] are transmembrane proteins that bind to ligands such as epinephrine, glucagon, and communicates the conditions of the cell to the nucleus or some other parts of the cell. There are many different classes and forms of GPCRs depending on their functonal
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G-Protein Coupled Receptors (GPCR), also known as 7 transmembrane (7TM) receptors [because of its 7 constituent alpha helices] are the largest groups of transmembrane protein receptors in eukaryotes and they bind to wide varieties of ligands such as epinephrine, glucagon, insulin, light, and sugars. They act as a bridge and communicate the conditions of the cell to the nucleus to induce transcription or affect the processivity of catalytic pathway. There are many different classes GPCRs depending on their functionality.

Revision as of 20:40, 5 November 2018

This Sandbox is Reserved from November 5 2018 through January 1, 2019 for use in the course "CHEM 4923: Senior Project taught by Christina R. Bourne at the University of Oklahoma, Norman, USA. This reservation includes Sandbox Reserved 1471 through Sandbox Reserved 1478.
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References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

THE GENUIS OF GPCRs.

INTRODUCTION.

Within the course of our daily activities, we experience several situations that cause us to jump on our feet and also, initiate some kind of response to these situations. Our bodies have an outstanding way of preparing us for such events as to whether flee or fight and it does this by making energy in the form of glucose available in the blood to support our reactions to these events. Our response is effectively mediated through reflex actions which are propagated through networks of neurons that are wired all over our body and eventually to the brain. One of the neurotransmitters produced through the coordination of these neuronal networks is epinephrine. Epinephrine serves as a ligand that bind to a transmembrane protein called GPCR and initiates a sequence of cascading pathways further downstream, that eventually results in the release of glucose into the blood to support the response we carry out.

FUNCTIONS

G-Protein Coupled Receptors (GPCR), also known as 7 transmembrane (7TM) receptors [because of its 7 constituent alpha helices] are the largest groups of transmembrane protein receptors in eukaryotes and they bind to wide varieties of ligands such as epinephrine, glucagon, insulin, light, and sugars. They act as a bridge and communicate the conditions of the cell to the nucleus to induce transcription or affect the processivity of catalytic pathway. There are many different classes GPCRs depending on their functionality.

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