2v22

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|SITE= <scene name='pdbsite=AC1:C35+Binding+Site+For+Residue+B+1433'>AC1</scene> and <scene name='pdbsite=AC2:C35+Binding+Site+For+Residue+D+1433'>AC2</scene>
|SITE= <scene name='pdbsite=AC1:C35+Binding+Site+For+Residue+B+1433'>AC1</scene> and <scene name='pdbsite=AC2:C35+Binding+Site+For+Residue+D+1433'>AC2</scene>
|LIGAND= <scene name='pdbligand=C35:N~2~-{[1-(4-CHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOL-3-YL]CARBONYL}-N~5~-(DIAMINOMETHYLIDENE)-L-ORNITHYL-L-LEUCYL-L-ISOLEUCYL-4-FLUORO-L-PHENYLALANINAMIDE'>C35</scene>
|LIGAND= <scene name='pdbligand=C35:N~2~-{[1-(4-CHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOL-3-YL]CARBONYL}-N~5~-(DIAMINOMETHYLIDENE)-L-ORNITHYL-L-LEUCYL-L-ISOLEUCYL-4-FLUORO-L-PHENYLALANINAMIDE'>C35</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1]
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
|GENE=
|GENE=
 +
|DOMAIN=
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|RELATEDENTRY=[[1aq1|1AQ1]], [[1b38|1B38]], [[1b39|1B39]], [[1buh|1BUH]], [[1ckp|1CKP]], [[1di8|1DI8]], [[1dm2|1DM2]], [[1e1v|1E1V]], [[1e1x|1E1X]], [[1e9h|1E9H]], [[1f5q|1F5Q]], [[1fin|1FIN]], [[1fq1|1FQ1]], [[1fvt|1FVT]], [[1fvv|1FVV]], [[1g5s|1G5S]], [[1gih|1GIH]], [[1gii|1GII]], [[1gij|1GIJ]], [[1gy3|1GY3]], [[1gz8|1GZ8]], [[1h00|1H00]], [[1h01|1H01]], [[1h07|1H07]], [[1h08|1H08]], [[1h0v|1H0V]], [[1h0w|1H0W]], [[1h1p|1H1P]], [[1h1q|1H1Q]], [[1h1r|1H1R]], [[1h1s|1H1S]], [[1h24|1H24]], [[1h25|1H25]], [[1h26|1H26]], [[1h27|1H27]], [[1h28|1H28]], [[1hck|1HCK]], [[1hcl|1HCL]], [[1jst|1JST]], [[1jsu|1JSU]], [[1jsv|1JSV]], [[1jvp|1JVP]], [[1ke5|1KE5]], [[1ke6|1KE6]], [[1ke7|1KE7]], [[1ke8|1KE8]], [[1ke9|1KE9]], [[1ogu|1OGU]], [[1oi9|1OI9]], [[1oiq|1OIQ]], [[1oir|1OIR]], [[1oit|1OIT]], [[1oiu|1OIU]], [[1oiy|1OIY]], [[1okv|1OKV]], [[1okw|1OKW]], [[1ol1|1OL1]], [[1ol2|1OL2]], [[1p2a|1P2A]], [[1p5e|1P5E]], [[1pf8|1PF8]], [[1pkd|1PKD]], [[1pw2|1PW2]], [[1pxi|1PXI]], [[1pxj|1PXJ]], [[1pxk|1PXK]], [[1pxl|1PXL]], [[1pxm|1PXM]], [[1pxn|1PXN]], [[1pxo|1PXO]], [[1pxp|1PXP]], [[1pye|1PYE]], [[1qmz|1QMZ]], [[1r78|1R78]], [[1urc|1URC]], [[1urw|1URW]], [[1v1k|1V1K]], [[1vyw|1VYW]], [[1vyz|1VYZ]], [[1w0x|1W0X]], [[1w8c|1W8C]], [[1w98|1W98]], [[1wcc|1WCC]], [[1y8y|1Y8Y]], [[1y91|1Y91]], [[1ykr|1YKR]], [[2a0c|2A0C]], [[2a4l|2A4L]], [[2b52|2B52]], [[2b53|2B53]], [[2b54|2B54]], [[2b55|2B55]], [[2bhe|2BHE]], [[2bhh|2BHH]], [[2bkz|2BKZ]], [[2bpm|2BPM]], [[2btr|2BTR]], [[2bts|2BTS]], [[2c4g|2C4G]], [[2c5n|2C5N]], [[2c5o|2C5O]], [[2c5p|2C5P]], [[2c5t|2C5T]], [[2c5v|2C5V]], [[2c5x|2C5X]], [[2c5y|2C5Y]], [[2c68|2C68]], [[2c69|2C69]], [[2c6i|2C6I]], [[2c6k|2C6K]], [[2c6l|2C6L]], [[2c6m|2C6M]], [[2c6o|2C6O]], [[2c6t|2C6T]], [[2cch|2CCH]], [[2cci|2CCI]], [[2cjm|2CJM]], [[2clx|2CLX]], [[2exm|2EXM]], [[2iw6|2IW6]], [[2iw8|2IW8]], [[2iw9|2IW9]], [[2j9m|2J9M]], [[2jgz|2JGZ]], [[2uue|2UUE]], [[2uzb|2UZB]], [[2uzd|2UZD]], [[2uze|2UZE]], [[2uzl|2UZL]], [[2uzn|2UZN]], [[2uzo|2UZO]], [[2v0d|2V0D]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v22 OCA], [http://www.ebi.ac.uk/pdbsum/2v22 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v22 RCSB]</span>
}}
}}
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[[Category: Mcinnes, C.]]
[[Category: Mcinnes, C.]]
[[Category: Plater, A.]]
[[Category: Plater, A.]]
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[[Category: C35]]
 
[[Category: active]]
[[Category: active]]
[[Category: atp-binding]]
[[Category: atp-binding]]
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[[Category: transferase]]
[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:42:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:07:38 2008''

Revision as of 02:07, 31 March 2008

Image:2v22.jpg


PDB ID 2v22

Drag the structure with the mouse to rotate
, resolution 2.60Å
Sites: and
Ligands:
Activity: Non-specific serine/threonine protein kinase, with EC number 2.7.11.1
Related: 1AQ1, 1B38, 1B39, 1BUH, 1CKP, 1DI8, 1DM2, 1E1V, 1E1X, 1E9H, 1F5Q, 1FIN, 1FQ1, 1FVT, 1FVV, 1G5S, 1GIH, 1GII, 1GIJ, 1GY3, 1GZ8, 1H00, 1H01, 1H07, 1H08, 1H0V, 1H0W, 1H1P, 1H1Q, 1H1R, 1H1S, 1H24, 1H25, 1H26, 1H27, 1H28, 1HCK, 1HCL, 1JST, 1JSU, 1JSV, 1JVP, 1KE5, 1KE6, 1KE7, 1KE8, 1KE9, 1OGU, 1OI9, 1OIQ, 1OIR, 1OIT, 1OIU, 1OIY, 1OKV, 1OKW, 1OL1, 1OL2, 1P2A, 1P5E, 1PF8, 1PKD, 1PW2, 1PXI, 1PXJ, 1PXK, 1PXL, 1PXM, 1PXN, 1PXO, 1PXP, 1PYE, 1QMZ, 1R78, 1URC, 1URW, 1V1K, 1VYW, 1VYZ, 1W0X, 1W8C, 1W98, 1WCC, 1Y8Y, 1Y91, 1YKR, 2A0C, 2A4L, 2B52, 2B53, 2B54, 2B55, 2BHE, 2BHH, 2BKZ, 2BPM, 2BTR, 2BTS, 2C4G, 2C5N, 2C5O, 2C5P, 2C5T, 2C5V, 2C5X, 2C5Y, 2C68, 2C69, 2C6I, 2C6K, 2C6L, 2C6M, 2C6O, 2C6T, 2CCH, 2CCI, 2CJM, 2CLX, 2EXM, 2IW6, 2IW8, 2IW9, 2J9M, 2JGZ, 2UUE, 2UZB, 2UZD, 2UZE, 2UZL, 2UZN, 2UZO, 2V0D


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



REPLACE: A STRATEGY FOR ITERATIVE DESIGN OF CYCLIN BINDING GROOVE INHIBITORS


Overview

We describe a drug-design strategy termed REPLACE (REplacement with Partial Ligand Alternatives through Computational Enrichment) in which nonpeptidic surrogates for specific determinants of known peptide ligands are identified in silico by using a core peptide-bound protein structure as a design anchor. In the REPLACE application example, we present the effective replacement of two critical binding motifs in a lead protein-protein interaction inhibitor pentapeptide with more druglike phenyltriazole and diphenyl ether groups. These were identified through docking of fragment libraries into the volume of the cyclin-binding groove of CDK2/cyclin A vacated through truncation of the inhibitor peptide-binding determinants. Proof of concept for this strategy was obtained through the generation of potent peptide-small-molecule hybrids and by the confirmation of inhibitor-binding modes in X-ray crystal structures. This method therefore allows nonpeptide fragments to be identified without the requirement for a high-sensitivity binding assay and should be generally applicable in replacing amino acids as individual residues or groups in peptide inhibitors to generate pharmaceutically acceptable lead molecules.

About this Structure

2V22 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

REPLACE: a strategy for iterative design of cyclin-binding groove inhibitors., Andrews MJ, Kontopidis G, McInnes C, Plater A, Innes L, Cowan A, Jewsbury P, Fischer PM, Chembiochem. 2006 Dec;7(12):1909-15. PMID:17051658

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