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Sialidase
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load=' | + | <StructureSection load='2w68' size='340' side='right' caption='Caption for this structure' scene=''> |
== Function == | == Function == | ||
| - | '''Sialidase''' is a neuraminidase which cleaves terminal sialic acid from a variety of natural substances <ref>PMID:12374200</ref>. | + | '''Sialidase''' is a neuraminidase which cleaves terminal sialic acid from a variety of natural substances <ref>PMID:12374200</ref>. The sialic acid-binding domain of sialidase is called CBD. For '''Anhydrosialidase''' catalyzes the elimination of sialyl group in N-acetylneuraminic acid glycosides to yield 2,7-anhydro-α-N-acetylneuraminate. For '''Trans-sialidase''' see [[Neuraminidase]]. |
== Disease == | == Disease == | ||
== Relevance == | == Relevance == | ||
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| - | ''Trypanosoma cruzi'' trans-sialidase is a drug target agains Chagas Disease<ref>PMID:24144418</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
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**[[1n1v]] – TrSal + neuraminic acid derivative <br /> | **[[1n1v]] – TrSal + neuraminic acid derivative <br /> | ||
**[[1mz6]], [[1n1t]], [[2ags]] – TrSal + inhibitor <br /> | **[[1mz6]], [[1n1t]], [[2ags]] – TrSal + inhibitor <br /> | ||
| - | **[[1n1y]]– TrSal + sialic acid <br /> | + | **[[1n1y]] – TrSal + sialic acid <br /> |
**[[2a75]], [[2fhr]] – TrSal + sialic acid derivative<br /> | **[[2a75]], [[2fhr]] – TrSal + sialic acid derivative<br /> | ||
**[[1dim]], [[1dil]], [[2sil]], [[2sim]] – StSal + inhibitor <br /> | **[[1dim]], [[1dil]], [[2sil]], [[2sim]] – StSal + inhibitor <br /> | ||
Revision as of 08:41, 7 November 2018
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3D structures of salidase
Updated on 07-November-2018
References
- ↑ Monti E, Preti A, Venerando B, Borsani G. Recent development in mammalian sialidase molecular biology. Neurochem Res. 2002 Aug;27(7-8):649-63. PMID:12374200
