2v43
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2v42|2V42]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v43 OCA], [http://www.ebi.ac.uk/pdbsum/2v43 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v43 RCSB]</span> | ||
}} | }} | ||
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[[Category: Wollmann, P.]] | [[Category: Wollmann, P.]] | ||
[[Category: Zeth, K.]] | [[Category: Zeth, K.]] | ||
| - | [[Category: CYS]] | ||
[[Category: lipoprotein binding]] | [[Category: lipoprotein binding]] | ||
[[Category: periplasmic]] | [[Category: periplasmic]] | ||
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[[Category: sensor for periplasmic stress]] | [[Category: sensor for periplasmic stress]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:08:17 2008'' |
Revision as of 02:08, 31 March 2008
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| , resolution 2.37Å | |||||||
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| Sites: | |||||||
| Ligands: | |||||||
| Related: | 2V42
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF RSEB: A SENSOR FOR PERIPLASMIC STRESS RESPONSE IN E. COLI
Overview
An elegant network of signal transduction has evolved in the bacterial cell envelope to respond to environmental stress. It is initiated by sensing unfavourable and harmful changes in the periplasm. The stress signal is then transmitted by a controlled degradation of the transmembrane anti-sigma-factor RseA that leads to the activation of the alternative sigma factor sigma(E). The periplasmic protein RseB exerts a crucial role in modulating the stability of RseA. RseB from Escherichia coli has been crystallized and crystal structures were determined at 2.4 A and at 2.8 A resolution. The protein forms a homodimer, with the monomer composed of two domains. The large domain resembles an unclosed beta-barrel that is structurally remarkably similar to a protein family capable of binding the lipid anchor of lipoproteins. The small C-terminal domain, connected to the large domain by a partially unstructured loop, is responsible for interaction with RseA. On the basis of the structure of RseB, we suggest that it acts as a sensor of periplasmic stress with a dual functionality: it detects mislocalized lipoproteins and propagates the signal to induce the sigma(E)-response.
About this Structure
2V43 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
The structure of RseB: a sensor in periplasmic stress response of E. coli., Wollmann P, Zeth K, J Mol Biol. 2007 Sep 28;372(4):927-41. Epub 2007 Jun 19. PMID:17692869
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