2v5p
From Proteopedia
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|PDB= 2v5p |SIZE=350|CAPTION= <scene name='initialview01'>2v5p</scene>, resolution 4.10Å | |PDB= 2v5p |SIZE=350|CAPTION= <scene name='initialview01'>2v5p</scene>, resolution 4.10Å | ||
|SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Nag+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC5:Bma+Binding+Site+For+Chain+A'>AC5</scene>, <scene name='pdbsite=AC6:Nag+Binding+Site+For+Chain+B'>AC6</scene>, <scene name='pdbsite=AC7:Nag+Binding+Site+For+Chain+B'>AC7</scene> and <scene name='pdbsite=AC8:Bma+Binding+Site+For+Chain+A'>AC8</scene> | |SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Nag+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC5:Bma+Binding+Site+For+Chain+A'>AC5</scene>, <scene name='pdbsite=AC6:Nag+Binding+Site+For+Chain+B'>AC6</scene>, <scene name='pdbsite=AC7:Nag+Binding+Site+For+Chain+B'>AC7</scene> and <scene name='pdbsite=AC8:Bma+Binding+Site+For+Chain+A'>AC8</scene> | ||
| - | |LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | + | |LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1gf2|1GF2]], [[1igl|1IGL]], [[1e6f|1E6F]], [[1gp0|1GP0]], [[1gp3|1GP3]], [[1gqb|1GQB]], [[1jpl|1JPL]], [[1jwg|1JWG]], [[1lf8|1LF8]], [[2cnj|2CNJ]], [[2v5n|2V5N]], [[2v5o|2V5O]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5p OCA], [http://www.ebi.ac.uk/pdbsum/2v5p PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v5p RCSB]</span> | ||
}} | }} | ||
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[[Category: Wallace, J C.]] | [[Category: Wallace, J C.]] | ||
[[Category: Zaccheo, O J.]] | [[Category: Zaccheo, O J.]] | ||
| - | [[Category: NAG]] | ||
[[Category: beta barrel]] | [[Category: beta barrel]] | ||
[[Category: cation independent mannose 6-phosphate]] | [[Category: cation independent mannose 6-phosphate]] | ||
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[[Category: transport]] | [[Category: transport]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:08:33 2008'' |
Revision as of 02:08, 31 March 2008
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| , resolution 4.10Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | , , , , , and | ||||||
| Ligands: | , | ||||||
| Related: | 1GF2, 1IGL, 1E6F, 1GP0, 1GP3, 1GQB, 1JPL, 1JWG, 1LF8, 2CNJ, 2V5N, 2V5O
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
COMPLEX STRUCTURE OF HUMAN IGF2R DOMAINS 11-13 BOUND TO IGF-II
Overview
Embryonic development and normal growth require exquisite control of insulin-like growth factors (IGFs). In mammals the extracellular region of the cation-independent mannose-6-phosphate receptor has gained an IGF-II-binding function and is termed type II IGF receptor (IGF2R). IGF2R sequesters IGF-II; imbalances occur in cancers and IGF2R is implicated in tumour suppression. We report crystal structures of IGF2R domains 11-12, 11-12-13-14 and domains 11-12-13/IGF-II complex. A distinctive juxtaposition of these domains provides the IGF-II-binding unit, with domain 11 directly interacting with IGF-II and domain 13 modulating binding site flexibility. Our complex shows that Phe19 and Leu53 of IGF-II lock into a hydrophobic pocket unique to domain 11 of mammalian IGF2Rs. Mutagenesis analyses confirm this IGF-II 'binding-hotspot', revealing that IGF-binding proteins and IGF2R have converged on the same high-affinity site.
About this Structure
2V5P is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure and functional analysis of the IGF-II/IGF2R interaction., Brown J, Delaine C, Zaccheo OJ, Siebold C, Gilbert RJ, van Boxel G, Denley A, Wallace JC, Hassan AB, Forbes BE, Jones EY, EMBO J. 2008 Jan 9;27(1):265-76. Epub 2007 Nov 29. PMID:18046459
Page seeded by OCA on Mon Mar 31 05:08:33 2008
Categories: Homo sapiens | Protein complex | Boxel, G Van. | Brown, J. | Delaine, C. | Denley, A. | Forbes, B E. | Gilbert, R J. | Hassan, A B. | Jones, E Y. | Siebold, C. | Wallace, J C. | Zaccheo, O J. | Beta barrel | Cation independent mannose 6-phosphate | Fibronectin type ii | Glycoprotein | Insulin-like growth factor | Lysosome | Membrane | Phosphorylation | Polymorphism | Receptor | Receptor/glycoprotein complex | Transmembrane | Transport
