6bic

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'''Unreleased structure'''
 
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The entry 6bic is ON HOLD until Paper Publication
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==2.25 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic inhibitor==
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<StructureSection load='6bic' size='340' side='right' caption='[[6bic]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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Authors: Lovell, S., Battaile, K.P., Mehzabeen, N., Kankanamalage, A.C.G., Weerawarna, P.M., Rathnayake, A.D., Kim, Y., Chang, K.O., Groutas, W.C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6bic]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BIC FirstGlance]. <br>
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Description: 2.25 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic inhibitor
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5LH:(PHENYLMETHYL)+~{N}-[(9~{S},12~{S},15~{S})-9-(HYDROXYMETHYL)-12-(2-METHYLPROPYL)-6,11,14-TRIS(OXIDANYLIDENE)-1,5,10,13,18,19-HEXAZABICYCLO[15.2.1]ICOSA-17(20),18-DIEN-15-YL]CARBAMATE'>5LH</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calicivirin Calicivirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.66 3.4.22.66] </span></td></tr>
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[[Category: Groutas, W.C]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bic OCA], [http://pdbe.org/6bic PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bic RCSB], [http://www.ebi.ac.uk/pdbsum/6bic PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bic ProSAT]</span></td></tr>
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[[Category: Battaile, K.P]]
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</table>
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[[Category: Mehzabeen, N]]
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== Function ==
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[[Category: Weerawarna, P.M]]
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[[http://www.uniprot.org/uniprot/POLG_NVN68 POLG_NVN68]] Protein p48 may play a role in viral replication by interacting with host VAPA, a vesicle-associated membrane protein that plays a role in SNARE-mediated vesicle fusion. This interaction may target replication complex to intracellular membranes.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> NTPase presumably plays a role in replication. Despite having similarities with helicases, does not seem to display any helicase activity.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> Protein P22 may play a role in targeting replication complex to intracellular membranes.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> 3C-like protease processes the polyprotein: 3CLpro-RdRp is first released by autocleavage, then all other proteins are cleaved. May cleave host polyadenylate-binding protein thereby inhibiting cellular translation (By similarity).<ref>PMID:569187</ref> <ref>PMID:11160659</ref> RNA-directed RNA polymerase replicates genomic and antigenomic RNA by recognizing replications specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA encodes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).<ref>PMID:569187</ref> <ref>PMID:11160659</ref>
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[[Category: Kankanamalage, A.C.G]]
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== References ==
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[[Category: Chang, K.O]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Calicivirin]]
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[[Category: Battaile, K P]]
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[[Category: Chang, K O]]
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[[Category: Groutas, W C]]
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[[Category: Kankanamalage, A C.G]]
[[Category: Kim, Y]]
[[Category: Kim, Y]]
[[Category: Lovell, S]]
[[Category: Lovell, S]]
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[[Category: Rathnayake, A.D]]
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[[Category: Mehzabeen, N]]
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[[Category: Rathnayake, A D]]
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[[Category: Weerawarna, P M]]
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[[Category: Antiviral inhibitor]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Norovirus]]
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[[Category: Norwalk virus]]
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[[Category: Protease]]
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[[Category: Triazole-based macrocyclic inhibitor]]

Revision as of 12:12, 7 November 2018

2.25 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic inhibitor

6bic, resolution 2.25Å

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