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6eaq
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Glycosylated FCGR3B / CD16b in complex with afucosylated IgG1 Fc== | |
| - | + | <StructureSection load='6eaq' size='340' side='right' caption='[[6eaq]], [[Resolution|resolution]] 2.22Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6eaq]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EAQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eaq OCA], [http://pdbe.org/6eaq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eaq RCSB], [http://www.ebi.ac.uk/pdbsum/6eaq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eaq ProSAT]</span></td></tr> |
| - | [[Category: Barb, A | + | </table> |
| - | [[Category: Roberts, J | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/IGG1_HUMAN IGG1_HUMAN]] Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).<ref>PMID:17576170</ref> <ref>PMID:20176268</ref> <ref>PMID:22158414</ref> [[http://www.uniprot.org/uniprot/FCG3B_HUMAN FCG3B_HUMAN]] Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Barb, A W]] | ||
| + | [[Category: Roberts, J T]] | ||
| + | [[Category: Cd16b]] | ||
| + | [[Category: Fcgr3b]] | ||
| + | [[Category: Glycoprotein]] | ||
| + | [[Category: Glycosylation]] | ||
| + | [[Category: Igg1 fc]] | ||
| + | [[Category: Immune system]] | ||
Revision as of 12:15, 7 November 2018
Glycosylated FCGR3B / CD16b in complex with afucosylated IgG1 Fc
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Categories: Barb, A W | Roberts, J T | Cd16b | Fcgr3b | Glycoprotein | Glycosylation | Igg1 fc | Immune system
