6hco

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'''Unreleased structure'''
 
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The entry 6hco is ON HOLD
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==Cryo-EM structure of the ABCG2 E211Q mutant bound to estrone 3-sulfate and 5D3-Fab==
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<StructureSection load='6hco' size='340' side='right' caption='[[6hco]], [[Resolution|resolution]] 3.58&Aring;' scene=''>
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Authors: Manolaridis, I., Jackson, S.M., Taylor, N.M.I., Kowal, J., Stahlberg, H., Locher, K.P.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6hco]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HCO FirstGlance]. <br>
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Description: Cryo-EM structure of the ABCG2 E211Q mutant bound to estrone 3-sulfate and 5D3-Fab
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FY5:estrone+3-sulfate'>FY5</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hco OCA], [http://pdbe.org/6hco PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hco RCSB], [http://www.ebi.ac.uk/pdbsum/6hco PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hco ProSAT]</span></td></tr>
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[[Category: Locher, K.P]]
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</table>
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[[Category: Jackson, S.M]]
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== Function ==
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[[http://www.uniprot.org/uniprot/ABCG2_HUMAN ABCG2_HUMAN]] High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.<ref>PMID:12958161</ref> <ref>PMID:20705604</ref> <ref>PMID:22132962</ref> <ref>PMID:23189181</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Jackson, S M]]
[[Category: Kowal, J]]
[[Category: Kowal, J]]
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[[Category: Locher, K P]]
[[Category: Manolaridis, I]]
[[Category: Manolaridis, I]]
[[Category: Stahlberg, H]]
[[Category: Stahlberg, H]]
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[[Category: Taylor, N.M.I]]
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[[Category: Taylor, N M.I]]
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[[Category: Cancer]]
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[[Category: Membrane protein]]
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[[Category: Multidrug transporter]]

Revision as of 12:22, 7 November 2018

Cryo-EM structure of the ABCG2 E211Q mutant bound to estrone 3-sulfate and 5D3-Fab

6hco, resolution 3.58Å

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