6mks
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of NLRC4-CARD filament== | |
| - | + | <StructureSection load='6mks' size='340' side='right' caption='[[6mks]], [[Resolution|resolution]] 3.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6mks]] is a 31 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MKS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MKS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mks OCA], [http://pdbe.org/6mks PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mks RCSB], [http://www.ebi.ac.uk/pdbsum/6mks PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mks ProSAT]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[Category: Egelman, E | + | == Disease == |
| + | [[http://www.uniprot.org/uniprot/NLRC4_HUMAN NLRC4_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NLRC4_HUMAN NLRC4_HUMAN]] Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity).[UniProtKB:Q3UP24]<ref>PMID:15107016</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Egelman, E H]] | ||
| + | [[Category: Matyszewski, M]] | ||
[[Category: Sohn, J]] | [[Category: Sohn, J]] | ||
| - | [[Category: Matyszewski, M]] | ||
[[Category: Zheng, W]] | [[Category: Zheng, W]] | ||
| + | [[Category: Helical assembly]] | ||
| + | [[Category: Inflammasome]] | ||
| + | [[Category: Nlrc4]] | ||
| + | [[Category: Protein fibril]] | ||
Revision as of 12:25, 7 November 2018
Cryo-EM structure of NLRC4-CARD filament
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