Thiamin phosphate synthase

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Revision as of 11:31, 11 November 2018

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spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function Thiamin phosphate synthase (TPS) catalyzes the synthesisd of 4-methyl-5 (β-hydroxyethyl)thiazole phosphate (thz-P) amd 4-amino-5(hydroxymethyl)-2-methylpyrimidine pyrophosphate (HMP-PP) to produce thiamin phosphate and pyrophosphate[1] Disease Relevance Structural highlights

1g4e, 3o16 - BsTPS (mutant) - Bacillus subtilis
1g4p - BsTPS (mutant) + pyrimidine derivative
1g67, 1g69, 1g6c - BsTPS (mutant) + pyrimidine derivative + PPi
1g4t - BsTPS + thiamine phosphate derivative
1g4s - BsTPS (mutant) + thiamine phosphate derivative
2tps - BsTPS + thiamine phosphate derivative + PPi
3o15 - BsTPS + thiazole phosphate derivative + PPi
3o63 - TPS + Pi - Mycobacterium tuberculosis
1xi3 - TPS - Pyrococcus furiosus

References

1. ↑ Reddick JJ, Nicewonger R, Begley TP. Mechanistic studies on thiamin phosphate synthase: evidence for a dissociative mechanism. Biochemistry. 2001 Aug 28;40(34):10095-102. PMID:11513588