Colony-stimulating factor
From Proteopedia
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| - | + | <StructureSection load='4wrl' size='340' side='right' caption='Caption for this structure' scene=''> | |
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This is a default text for your page '''Colony-stimulating factor'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page '''Colony-stimulating factor'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
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== Function == | == Function == | ||
| - | '''Colony-stimulating factor'''s (CSF) are growth regulatory factors which influence functional activity, survival, proliferation and differentiation of myeloid mature and haemopoietic cells. | + | '''Colony-stimulating factor'''s (CSF) are growth regulatory factors which influence functional activity, survival, proliferation and differentiation of myeloid mature and haemopoietic cells. Four distinct CSFs were characterized<ref>PMID:9360058</ref>.<br /> |
*'''Granulocyte colony-stimulating factor''' (G-CSF) act on proliferation, functional stimulation and differentiation of progenitors of neutrophils.<br /> | *'''Granulocyte colony-stimulating factor''' (G-CSF) act on proliferation, functional stimulation and differentiation of progenitors of neutrophils.<br /> | ||
| - | *'''Granulocyte-macrophage colony-stimulating factor''' (GM-CSF) act on proliferation, functional stimulation and differentiation of progenitors of neutrophils, monocytes and granulocytes.<br /> | + | *'''Granulocyte-macrophage colony-stimulating factor''' (GM-CSF) act on proliferation, functional stimulation and differentiation of progenitors of neutrophils, monocytes and granulocytes<ref>PMID:16474424</ref>.<br /> |
*'''Macrophage colony-stimulating factor''' (M-CSF) act on proliferation, functional stimulation and differentiation of progenitors of monocytes and macrophages.<br /> | *'''Macrophage colony-stimulating factor''' (M-CSF) act on proliferation, functional stimulation and differentiation of progenitors of monocytes and macrophages.<br /> | ||
| + | *'''multi-colony-stimulating factor''' also known as interleukin 3.<br /> | ||
== Disease == | == Disease == | ||
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== Relevance == | == Relevance == | ||
| - | + | Depletion of CSFs have therapeutic benefit in many inflammatory and autoimmune conditions<ref>PMID:18551128</ref>. G-CSF and GM-CSF are used to increase low white blood cell levels in cancer patients following chemotherapy and to release haematopoietic stem cells which replace bone marrow cells after anti-cancer treatments<ref>PMID:20495576</ref>. G-CSF is a neurotrophic factor and thus a candidate for the treatment of neurodegenerative conditions<ref>PMID:16258290</ref>. G-CSF and GN-CSF ar commercially available for clinical use<ref>PMID:1375975</ref>. | |
== Structural highlights == | == Structural highlights == | ||
| - | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
</StructureSection> | </StructureSection> | ||
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| + | ==3D structures of colony-stimulating factor== | ||
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| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| + | *Macrophage colony stimulating factor | ||
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| + | **[[2gmf]], [[3uf2]] - hM-CSF - human<br /> | ||
| + | **[[5lxf]] - hM-CSF (mutant)<br /> | ||
| + | **[[4adq]], [[4adf]] - hM-CSF + BARF1<br /> | ||
| + | **[[3uez]] - hM-CSF (mutant) + BARF1<br /> | ||
| + | **[[4wrm]], [[4wrl]] - hG-CSF + CSF receptor<br /> | ||
| + | **[[3uf5]] - mM-CSF - mouse<br /> | ||
| + | **[[3ejj]] - mM-CSF + CSF receptor<br /> | ||
| + | |||
| + | *Granulocyte-macrophage colony stimulating factor | ||
| + | |||
| + | **[[2gmf]], [[1csg]] - hGM-CSF<br /> | ||
| + | **[[5c7x]], [[5d70]], [[5d71]], [[5d72]], [[6bfq]], [[6bfs]] - hGM-CSF + antibody<br /> | ||
| + | **[[4rs1]] - hGM-CSF + CSF receptor<br /> | ||
| + | **[[4nkq]] - hGM-CSF + CSF receptor + cytokine receptor<br /> | ||
| + | **[[5d22]] - sGM-CSF - sheep<br /> | ||
| + | **[[5d28]] - sGM-CSF + CSF inhibition factor<br /> | ||
| + | |||
| + | *Granulocyte colony stimulating factor | ||
| + | |||
| + | **[[1bgc]] - G-CSF - bovine<br /> | ||
| + | **[[1bgd]], [[1bge]] - G-CSF - dog<br /> | ||
| + | **[[1rhg]] - hG-CSF <br /> | ||
| + | **[[1gnc]] - hG-CSF - NMR<br /> | ||
| + | **[[5gw9]] - hG-CSF (mutant)<br /> | ||
| + | **[[2d9q]], [[1pgr]], [[1cd9]] - hG-CSF + CSF receptor<br /> | ||
| + | **[[1gcf]], [[1cto]] - mG-CSF C-terminal of LBD - NMR<br /> | ||
| + | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
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| + | [[Category:Topic Page]] | ||
Revision as of 09:32, 13 November 2018
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3D structures of colony-stimulating factor
Updated on 13-November-2018
References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Nemunaitis J. A comparative review of colony-stimulating factors. Drugs. 1997 Nov;54(5):709-29. doi: 10.2165/00003495-199754050-00004. PMID:9360058 doi:http://dx.doi.org/10.2165/00003495-199754050-00004
- ↑ Shi Y, Liu CH, Roberts AI, Das J, Xu G, Ren G, Zhang Y, Zhang L, Yuan ZR, Tan HS, Das G, Devadas S. Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know. Cell Res. 2006 Feb;16(2):126-33. doi: 10.1038/sj.cr.7310017. PMID:16474424 doi:http://dx.doi.org/10.1038/sj.cr.7310017
- ↑ Hamilton JA. Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol. 2008 Jul;8(7):533-44. doi: 10.1038/nri2356. PMID:18551128 doi:http://dx.doi.org/10.1038/nri2356
- ↑ Metcalf D. The colony-stimulating factors and cancer. Nat Rev Cancer. 2010 Jun;10(6):425-34. doi: 10.1038/nrc2843. PMID:20495576 doi:http://dx.doi.org/10.1038/nrc2843
- ↑ Schneider A, Kuhn HG, Schabitz WR. A role for G-CSF (granulocyte-colony stimulating factor) in the central nervous system. Cell Cycle. 2005 Dec;4(12):1753-7. doi: 10.4161/cc.4.12.2213. Epub 2005 Dec 27. PMID:16258290 doi:http://dx.doi.org/10.4161/cc.4.12.2213
- ↑ Lieschke GJ, Burgess AW. Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor (1). N Engl J Med. 1992 Jul 2;327(1):28-35. doi: 10.1056/NEJM199207023270106. PMID:1375975 doi:http://dx.doi.org/10.1056/NEJM199207023270106
