6mgv
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of mechanically activated ion channel OSCA1.2 in nanodisc== | |
| + | <StructureSection load='6mgv' size='340' side='right' caption='[[6mgv]], [[Resolution|resolution]] 3.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6mgv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MGV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MGV FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6mgw|6mgw]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mgv OCA], [http://pdbe.org/6mgv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mgv RCSB], [http://www.ebi.ac.uk/pdbsum/6mgv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mgv ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CSC1_ARATH CSC1_ARATH]] Acts as an osmosensitive calcium-permeable cation channel. Specifically conducts cations including Ca(2+), K(+) and Na(+) in vitro. Inactivation or closure of the channel is calcium-dependent.<ref>PMID:24503647</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Mechanically activated ion channels underlie touch, hearing, shear-stress sensing, and response to turgor pressure. OSCA/TMEM63s are a newly-identified family of eukaryotic mechanically activated ion channels opened by membrane tension. The structural underpinnings of OSCA/TMEM63 function are not explored. Here, we elucidate high resolution cryo-electron microscopy structures of OSCA1.2, revealing a dimeric architecture containing eleven transmembrane helices per subunit and surprising topological similarities to TMEM16 proteins. We locate the ion permeation pathway within each subunit by demonstrating that a conserved acidic residue is a determinant of channel conductance. Molecular dynamics simulations reveal membrane interactions, suggesting the role of lipids in OSCA1.2 gating. These results lay a foundation to decipher how the structural organization of OSCA/TMEM63 is suited for their roles as MA ion channels. | ||
| - | + | Cryo-EM structure of the mechanically activated ion channel OSCA1.2.,Jojoa Cruz S, Saotome K, Murthy SE, Tsui CCA, Sansom MS, Patapoutian A, Ward AB Elife. 2018 Nov 1;7. pii: 41845. doi: 10.7554/eLife.41845. PMID:30382939<ref>PMID:30382939</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | [[Category: | + | <div class="pdbe-citations 6mgv" style="background-color:#fffaf0;"></div> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Jojoa-Cruz, S]] | ||
[[Category: Patapoutian, A]] | [[Category: Patapoutian, A]] | ||
[[Category: Saotome, K]] | [[Category: Saotome, K]] | ||
| - | [[Category: | + | [[Category: Ward, A B]] |
| + | [[Category: Mechanically activated ion channel]] | ||
| + | [[Category: Membrane protein]] | ||
Revision as of 08:22, 14 November 2018
Structure of mechanically activated ion channel OSCA1.2 in nanodisc
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