2viz

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|PDB= 2viz |SIZE=350|CAPTION= <scene name='initialview01'>2viz</scene>, resolution 1.60&Aring;
|PDB= 2viz |SIZE=350|CAPTION= <scene name='initialview01'>2viz</scene>, resolution 1.60&Aring;
|SITE= <scene name='pdbsite=AC1:Vg4+Binding+Site+For+Chain+A'>AC1</scene>
|SITE= <scene name='pdbsite=AC1:Vg4+Binding+Site+For+Chain+A'>AC1</scene>
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|LIGAND= <scene name='pdbligand=VG4:'>VG4</scene>
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|LIGAND= <scene name='pdbligand=VG4:N-[(1S,2R)-1-BENZYL-3-{[(1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL]AMINO}-2-HYDROXYPROPYL]-3-(2-OXO-2,3-DIHYDRO-1H-PYRROL-1-YL)-5-PROPOXYBENZAMIDE'>VG4</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46]
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span>
|GENE=
|GENE=
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|DOMAIN=
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|RELATEDENTRY=[[1tqf|1TQF]], [[1xn3|1XN3]], [[1m4h|1M4H]], [[1xn2|1XN2]], [[2vie|2VIE]], [[2va6|2VA6]], [[2b8l|2B8L]], [[1ym4|1YM4]], [[2va5|2VA5]], [[1sgz|1SGZ]], [[1ujk|1UJK]], [[2b8v|2B8V]], [[1fkn|1FKN]], [[1xs7|1XS7]], [[2vij|2VIJ]], [[2va7|2VA7]], [[1ym2|1YM2]], [[1py1|1PY1]], [[1w50|1W50]], [[1ujj|1UJJ]], [[1w51|1W51]], [[2viy|2VIY]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2viz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2viz OCA], [http://www.ebi.ac.uk/pdbsum/2viz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2viz RCSB]</span>
}}
}}
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[[Category: Ward, J.]]
[[Category: Ward, J.]]
[[Category: Wayne, G.]]
[[Category: Wayne, G.]]
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[[Category: VG4]]
 
[[Category: alternative splicing]]
[[Category: alternative splicing]]
[[Category: asp-2]]
[[Category: asp-2]]
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[[Category: zymogen]]
[[Category: zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:47:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:13:01 2008''

Revision as of 02:13, 31 March 2008

Image:2viz.jpg


PDB ID 2viz

Drag the structure with the mouse to rotate
, resolution 1.60Å
Sites:
Ligands:
Activity: Memapsin 2, with EC number 3.4.23.46
Related: 1TQF, 1XN3, 1M4H, 1XN2, 2VIE, 2VA6, 2B8L, 1YM4, 2VA5, 1SGZ, 1UJK, 2B8V, 1FKN, 1XS7, 2VIJ, 2VA7, 1YM2, 1PY1, 1W50, 1UJJ, 1W51, 2VIY


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-(2-OXO-1-PYRROLIDINYL)-5-(PROPYLOXY) BENZAMIDE


Overview

Inhibition of the aspartyl protease BACE-1 has the potential to deliver a disease-modifying therapy for Alzheimer's disease. Herein, is described the lead generation effort which resulted, with the support of X-ray crystallography, in the discovery of potent inhibitors based on a hydroxy ethylamine (HEA) transition-state mimetic. These inhibitors were capable of lowering amyloid production in a cell-based assay.

About this Structure

2VIZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs)., Clarke B, Demont E, Dingwall C, Dunsdon R, Faller A, Hawkins J, Hussain I, MacPherson D, Maile G, Matico R, Milner P, Mosley J, Naylor A, O'Brien A, Redshaw S, Riddell D, Rowland P, Soleil V, Smith KJ, Stanway S, Stemp G, Sweitzer S, Theobald P, Vesey D, Walter DS, Ward J, Wayne G, Bioorg Med Chem Lett. 2008 Feb 1;18(3):1011-6. Epub 2007 Dec 15. PMID:18171614

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