2vlk

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|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
 +
|DOMAIN=
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|RELATEDENTRY=[[2vlr|2VLR]], [[2vll|2VLL]], [[2vlm|2VLM]], [[2vlj|2VLJ]], [[1uqs|1UQS]], [[1bd2|1BD2]], [[2ak4|2AK4]], [[1ypz|1YPZ]], [[1im3|1IM3]], [[1uxw|1UXW]], [[1i7u|1I7U]], [[1c16|1C16]], [[1hsa|1HSA]], [[2axf|2AXF]], [[1gzp|1GZP]], [[2bnq|2BNQ]], [[1w72|1W72]], [[2jcc|2JCC]], [[2bck|2BCK]], [[1de4|1DE4]], [[1n2r|1N2R]], [[1exu|1EXU]], [[1qrn|1QRN]], [[2hla|2HLA]], [[1mhe|1MHE]], [[1im9|1IM9]], [[1eez|1EEZ]], [[1jht|1JHT]], [[1qqd|1QQD]], [[1qr1|1QR1]], [[1zs8|1ZS8]], [[1hla|1HLA]], [[1jgd|1JGD]], [[1i1y|1I1Y]], [[1vgk|1VGK]], [[1age|1AGE]], [[1ur7|1UR7]], [[1hhg|1HHG]], [[1s9x|1S9X]], [[1a9e|1A9E]], [[1duz|1DUZ]], [[2clr|2CLR]], [[3hla|3HLA]], [[1m05|1M05]], [[1tvb|1TVB]], [[2v2w|2V2W]], [[1onq|1ONQ]], [[1a1n|1A1N]], [[1lp9|1LP9]], [[1zsd|1ZSD]], [[1m6o|1M6O]], [[2bsu|2BSU]], [[1hhk|1HHK]], [[1zt4|1ZT4]], [[1hsb|1HSB]], [[1x7q|1X7Q]], [[1ce6|1CE6]], [[1py4|1PY4]], [[1syv|1SYV]], [[2j8u|2J8U]], [[1sys|1SYS]], [[1ogt|1OGT]], [[1cg9|1CG9]], [[1p7q|1P7Q]], [[1q94|1Q94]], [[1jnj|1JNJ]], [[1agb|1AGB]], [[2d31|2D31]], [[1aqd|1AQD]], [[1xz0|1XZ0]], [[1lds|1LDS]], [[1hhh|1HHH]], [[1tvh|1TVH]], [[1xr8|1XR8]], [[2bss|2BSS]], [[1a1m|1A1M]], [[1e28|1E28]], [[2v2x|2V2X]], [[1xr9|1XR9]], [[2gj6|2GJ6]], [[1efx|1EFX]], [[1qlf|1QLF]], [[2av1|2AV1]], [[1tmc|1TMC]], [[1qsf|1QSF]], [[1duy|1DUY]], [[1jge|1JGE]], [[1kpr|1KPR]], [[2hjl|2HJL]], [[1qew|1QEW]], [[1w0v|1W0V]], [[1k5n|1K5N]], [[1ao7|1AO7]], [[2bnr|2BNR]], [[1xh3|1XH3]], [[2bst|2BST]], [[1mi5|1MI5]], [[2h26|2H26]], [[1s9y|1S9Y]], [[1a1o|1A1O]], [[1agf|1AGF]], [[2a83|2A83]], [[1oga|1OGA]], [[2f8o|2F8O]], [[2bsv|2BSV]], [[2cii|2CII]], [[1i7r|1I7R]], [[1jf1|1JF1]], [[2c7u|2C7U]], [[2f74|2F74]], [[1e27|1E27]], [[1w0w|1W0W]], [[1gzq|1GZQ]], [[1uxs|1UXS]], [[1akj|1AKJ]], [[2hjk|2HJK]], [[2vb5|2VB5]], [[1agd|1AGD]], [[1r3h|1R3H]], [[1eey|1EEY]], [[1i7t|1I7T]], [[1i4f|1I4F]], [[1ydp|1YDP]], [[2bsr|2BSR]], [[1b0g|1B0G]], [[1b0r|1B0R]], [[1of2|1OF2]], [[1hhi|1HHI]], [[1qse|1QSE]], [[1a9b|1A9B]], [[2axg|2AXG]], [[2bvq|2BVQ]], [[1agc|1AGC]], [[1hhj|1HHJ]], [[1qvo|1QVO]], [[1s9w|1S9W]], [[1ktl|1KTL]], [[1a6z|1A6Z]], [[2cik|2CIK]], [[2uwe|2UWE]], [[1i1f|1I1F]], [[2av7|2AV7]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vlk OCA], [http://www.ebi.ac.uk/pdbsum/2vlk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2vlk RCSB]</span>
}}
}}
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[[Category: ubl conjugation]]
[[Category: ubl conjugation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:47:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:13:27 2008''

Revision as of 02:13, 31 March 2008

Image:2vlk.jpg


PDB ID 2vlk

Drag the structure with the mouse to rotate
, resolution 2.50Å
Related: 2VLR, 2VLL, 2VLM, 2VLJ, 1UQS, 1BD2, 2AK4, 1YPZ, 1IM3, 1UXW, 1I7U, 1C16, 1HSA, 2AXF, 1GZP, 2BNQ, 1W72, 2JCC, 2BCK, 1DE4, 1N2R, 1EXU, 1QRN, 2HLA, 1MHE, 1IM9, 1EEZ, 1JHT, 1QQD, 1QR1, 1ZS8, 1HLA, 1JGD, 1I1Y, 1VGK, 1AGE, 1UR7, 1HHG, 1S9X, 1A9E, 1DUZ, 2CLR, 3HLA, 1M05, 1TVB, 2V2W, 1ONQ, 1A1N, 1LP9, 1ZSD, 1M6O, 2BSU, 1HHK, 1ZT4, 1HSB, 1X7Q, 1CE6, 1PY4, 1SYV, 2J8U, 1SYS, 1OGT, 1CG9, 1P7Q, 1Q94, 1JNJ, 1AGB, 2D31, 1AQD, 1XZ0, 1LDS, 1HHH, 1TVH, 1XR8, 2BSS, 1A1M, 1E28, 2V2X, 1XR9, 2GJ6, 1EFX, 1QLF, 2AV1, 1TMC, 1QSF, 1DUY, 1JGE, 1KPR, 2HJL, 1QEW, 1W0V, 1K5N, 1AO7, 2BNR, 1XH3, 2BST, 1MI5, 2H26, 1S9Y, 1A1O, 1AGF, 2A83, 1OGA, 2F8O, 2BSV, 2CII, 1I7R, 1JF1, 2C7U, 2F74, 1E27, 1W0W, 1GZQ, 1UXS, 1AKJ, 2HJK, 2VB5, 1AGD, 1R3H, 1EEY, 1I7T, 1I4F, 1YDP, 2BSR, 1B0G, 1B0R, 1OF2, 1HHI, 1QSE, 1A9B, 2AXG, 2BVQ, 1AGC, 1HHJ, 1QVO, 1S9W, 1KTL, 1A6Z, 2CIK, 2UWE, 1I1F, 2AV7


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



THE STRUCTURAL DYNAMICS AND ENERGETICS OF AN IMMUNODOMINANT T-CELL RECEPTOR ARE PROGRAMMED BY ITS VBETA DOMAIN


Overview

Immunodominant and public T cell receptor (TCR) usage is relatively common in many viral diseases yet surprising in the context of the large naive TCR repertoire. We examined the highly conserved Vbeta17:Valpha10.2 JM22 T cell response to the influenza matrix peptide (58-66)-HLA-A( *)0201 (HLA-A2-flu) through extensive kinetic, thermodynamic, and structural analyses. We found several conformational adjustments that accompany JM22-HLA-A2-flu binding and identified a binding "hotspot" within the Vbeta domain of the TCR. Within this hotspot, key germline-encoded CDR1 and CDR2 loop residues and a crucial but commonly coded residue in the hypervariable region of CDR3 provide the basis for the substantial bias in the selection of the germline-encoded Vbeta17 domain. The chances of having a substantial number of T cells in the naive repertoire that have HLA-A2-flu-specific Vbeta17 receptors may consequently be relatively high, thus explaining the immunodominant usage of this clonotype.

About this Structure

2VLK is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain., Ishizuka J, Stewart-Jones GB, van der Merwe A, Bell JI, McMichael AJ, Jones EY, Immunity. 2008 Feb;28(2):171-82. PMID:18275829

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