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Function

The organism in which the protein can be found in is ibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961). Its biological role has yet to be determined, VesB is produced both in vitro and in vivo. It has had detection in laboratory-grown culter. VesB is most likely produced as a zymogen because sequene alignment with trypsinogen identified a putative cleavage site for activation and a catalytic triad, His-Asp-Ser. VesB efficiently cleaved a trypsin substrate but not chymotrypsin and elastase substrates.

Disease

The role of this protein is to help with the prevention and survival of diseases. VesB has been detected in in V. Cholerae which has been isolated from stools of patients with clinical cholera. It is believed that it helps in intestinal growth of V. cholerae because it is found in V. cholerae. VesB is able to split the A subunit of choleratoxin. There is a chance that it helps in intestinal growth of V. cholerae. VesB is able to split the A subunit of choleratoxin.

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Structural highlights

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