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You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

Function

The organism PLpro is from is Coronaviruses. IBV PLpro performs deubiquitination with catalytic efficiencies that are different from other PLpros. Papain-like protease (PLpro) of coronaviruses (CoVs) carries out proteolytic maturation of non-structural proteins that play a role in replication of the virus and performs deubiquitination of host cell factors to scuttle antiviral responses. The substrates and products are PLpro and ubiquitin.

Disease

A disease associated with the protein is avian infectious bronchitis in poultry. The protein helps out with scuttling antiviral responses and when this protein is working it stops the host(chicken) from being able to keep the virus from replicating. Other diseases associated with PLpro include respiratory tract infections and uro-gential tract infections.

Relevance

The avian infectious bronchitis virus, IBV, causes bronchitis in chickens and results in huge economic losses every year in the poultry business, and it encodes a PLpro. Understanding how this protein works in the body can help us figure out how to fight this virus and stop the huge loss of chickens each year. The results from this can help provide a way to create antivirals for not only this virus but others as well. Since ubiquitination is not limited to immune responses, PLpros are probably capable of modulating other aspects of the host cell regulated by ubiquitination meaning their impact on the cells goes beyond just this and should be explored further.

Structural highlights

Here is a of PLpro, it's main secondary features are mainly beta sheets and with alpha helixes and a little less random coils. In this cartoon view the most important tertiary and quaternary structures of PLpro are highlighted This is a view of PLpro and it provides a view Here is a of PLpro, the importance of hydrophobic and hydrophilic regions are that they Here is a view of the ligand. The important chemical features of the ligand are This is the catalytic triad and it helps the protein achieve its function by The active site is pictured here and has the key amino acids highlighted. Those key amino acids are . h This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

This article compares the kinetic parameters of PLpros from different COVs. Sars COV followed by IBV had higher catalytic efficiencies than MERS COV. This information helps tell us what the proteins can cleave at a given catalytic efficiency. This allows them to see the relationship between the two and see at what catalytic efficiency can the protein still operate and function properly.