Galactoside O-acetyltransferase

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Revision as of 10:41, 20 November 2018

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spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Galactoside O-acetyltransferase (GAT) assists cellular detoxification by acetylating the 6-hydroxyl group of nonmetabolizable pyranosides like galactosides, glucosides and lactosides and thus preventing their reentry into the cell[1]. GAT gene is part of the lac operon[2]. Structural highlights

3D structures of galactoside O-acetyltransferase

Updated on 20-November-2018

1kqa, 1krr – EcGAT + Acetyl CoA – Escherichia coli
1kru, 1krv – EcGAT + Acetyl CoA + galactopyranose derivative
3ftt – SaGAT – Staphylococcus aureus
3v4e, 5u2k, 5v0z – SaGAT + Acetyl CoA
3vbi – BcGAT + Acetyl CoA + TDP derivative – Bacillus cereus
3vbn, 3vbp, 3vbk, 3vbl, 3vbm – BcGAT (mutant) + Acetyl CoA + TDP derivative
3vbj – BcGAT + butyryl CoA + TDP

References

1. ↑ Wang XG, Olsen LR, Roderick SL. Structure of the lac operon galactoside acetyltransferase. Structure. 2002 Apr;10(4):581-8. PMID:11937062
2. ↑ Roderick SL. The lac operon galactoside acetyltransferase. C R Biol. 2005 Jun;328(6):568-75. doi: 10.1016/j.crvi.2005.03.005. PMID:15950163 doi:http://dx.doi.org/10.1016/j.crvi.2005.03.005