Synaptosomal-associated protein

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== Structural highlights ==
== Structural highlights ==
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SNAP25 has two SNARE motifs - one at its N-terminal and the other at its C-terminal. These motives make complexes with [[Syntaxin]] and <ref>PMID:18596234</ref>.
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SNAP25 has two SNARE motifs - one at its N-terminal and the other at its C-terminal. These motives make complexes with [[Syntaxin]] and VAMP2<ref>PMID:18596234</ref>.
</StructureSection>
</StructureSection>

Revision as of 11:27, 29 November 2018

RAT neuronal SNARE complex containing SNAP25 N-terminal SNARE motif (gold), SNAP25 C-terminal SNARE motif (red), syntaxin-1a SNARE motif (cyan), VAMP2 SNARE motif (magenta), glycylglycylglycine and sulfate (PDB code 3hd7)

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3D structures of synaptosomal-associated protein

Updated on 29-November-2018

Updated on 29-November-2018 {{#tree:id=OrganizedByTopic|openlevels=0|


References

  1. ↑ Noor A, Zahid S. A review of the role of synaptosomal-associated protein 25 (SNAP-25) in neurological disorders. Int J Neurosci. 2017 Sep;127(9):805-811. doi: 10.1080/00207454.2016.1248240. Epub, 2016 Nov 1. PMID:27734716 doi:http://dx.doi.org/10.1080/00207454.2016.1248240
  2. ↑ Greber S, Lubec G, Cairns N, Fountoulakis M. Decreased levels of synaptosomal associated protein 25 in the brain of patients with Down syndrome and Alzheimer's disease. Electrophoresis. 1999 Apr-May;20(4-5):928-34. doi:, 10.1002/(SICI)1522-2683(19990101)20:4/5<928::AID-ELPS928>3.0.CO;2-Z. PMID:10344268 doi:<928::AID-ELPS928>3.0.CO;2-Z http://dx.doi.org/10.1002/(SICI)1522-2683(19990101)20:4/5<928::AID-ELPS928>3.0.CO;2-Z
  3. ↑ Wang L, Bittner MA, Axelrod D, Holz RW. The structural and functional implications of linked SNARE motifs in SNAP25. Mol Biol Cell. 2008 Sep;19(9):3944-55. doi: 10.1091/mbc.e08-04-0344. Epub 2008, Jul 2. PMID:18596234 doi:http://dx.doi.org/10.1091/mbc.e08-04-0344

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Michal Harel

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