5yvo

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'''Unreleased structure'''
 
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The entry 5yvo is ON HOLD until Paper Publication
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==Human Glutathione Transferase Omega1 covalently bound to ML175 inhibitor==
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<StructureSection load='5yvo' size='340' side='right' caption='[[5yvo]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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Authors: Saisawang, C., Ketterman, A., Wongsantichon, J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5yvo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YVO FirstGlance]. <br>
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Description: Human Glutathione Transferase Omega1 covalently bound to ML175 inhibitor
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MLX:N-{3-[(2-chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide'>MLX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GSTO1, GSTTLP28 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yvo OCA], [http://pdbe.org/5yvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yvo RCSB], [http://www.ebi.ac.uk/pdbsum/5yvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yvo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/GSTO1_HUMAN GSTO1_HUMAN]] Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.<ref>PMID:10783391</ref> <ref>PMID:11511179</ref> <ref>PMID:17226937</ref> <ref>PMID:18028863</ref> <ref>PMID:21106529</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Human]]
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[[Category: Ketterman, A]]
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[[Category: Saisawang, C]]
[[Category: Wongsantichon, J]]
[[Category: Wongsantichon, J]]
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[[Category: Saisawang, C]]
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[[Category: Allosteric]]
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[[Category: Ketterman, A]]
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[[Category: Gst]]
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[[Category: Inhibitor]]
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[[Category: Transferase]]

Revision as of 20:22, 2 December 2018

Human Glutathione Transferase Omega1 covalently bound to ML175 inhibitor

5yvo, resolution 1.80Å

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