6h1i
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human Pirin in complex with bisamide compound 2== | |
| - | + | <StructureSection load='6h1i' size='340' side='right' caption='[[6h1i]], [[Resolution|resolution]] 1.69Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6h1i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H1I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H1I FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FJH:~{N}-[5-(2,3-dihydro-1,4-benzodioxin-6-ylcarbonylamino)-2-methyl-phenyl]-2-methyl-quinoline-6-carboxamide'>FJH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | [[ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Quercetin_2,3-dioxygenase Quercetin 2,3-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.24 1.13.11.24] </span></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h1i OCA], [http://pdbe.org/6h1i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h1i RCSB], [http://www.ebi.ac.uk/pdbsum/6h1i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h1i ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PIR_HUMAN PIR_HUMAN]] Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro).<ref>PMID:9079676</ref> <ref>PMID:17288615</ref> <ref>PMID:20010624</ref> <ref>PMID:20711196</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Quercetin 2,3-dioxygenase]] | ||
[[Category: Ali, S]] | [[Category: Ali, S]] | ||
| + | [[Category: Bihan, Y V.Le]] | ||
| + | [[Category: Montfort, R L.M van]] | ||
| + | [[Category: 3-dioxygenase]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Quercetin 2]] | ||
| + | [[Category: Transcription]] | ||
| + | [[Category: Transcriptional coregulator]] | ||
Revision as of 20:33, 2 December 2018
Crystal structure of human Pirin in complex with bisamide compound 2
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