6i2k

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m (Protected "6i2k" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6i2k is ON HOLD
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==Structure of EV71 complexed with its receptor SCARB2==
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<StructureSection load='6i2k' size='340' side='right' caption='[[6i2k]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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Authors: Zhou, D., Zhao, Y., Kotecha, A., Fry, E.E., Kelly, J., Wang, X., Rao, Z., Rowlands, D.J., Ren, J., Stuart, D.I.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6i2k]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterovirus_a71 Enterovirus a71] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I2K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I2K FirstGlance]. <br>
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Description: Structure of EV71 complexed with its receptor SCARB2
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=906:1-(2-AMINOPYRIDIN-4-YL)-3-[(3S)-5-{4-[(E)-(ETHOXYIMINO)METHYL]PHENOXY}-3-METHYLPENTYL]IMIDAZOLIDIN-2-ONE'>906</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SCARB2, CD36L2, LIMP2, LIMPII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i2k OCA], [http://pdbe.org/6i2k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i2k RCSB], [http://www.ebi.ac.uk/pdbsum/6i2k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i2k ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/SCRB2_HUMAN SCRB2_HUMAN]] Unverricht-Lundborg disease;Gaucher disease type 1;Action myoclonus - renal failure syndrome. The disease is caused by mutations affecting the gene represented in this entry. Genetic variants in SCARB2 can act as modifier of the phenotypic expression and severity of Gaucher disease.
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== Function ==
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[[http://www.uniprot.org/uniprot/SCRB2_HUMAN SCRB2_HUMAN]] Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting.<ref>PMID:18022370</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Enterovirus a71]]
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[[Category: Human]]
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[[Category: Fry, E E]]
[[Category: Kelly, J]]
[[Category: Kelly, J]]
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[[Category: Kotecha, A]]
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[[Category: Rao, Z]]
[[Category: Ren, J]]
[[Category: Ren, J]]
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[[Category: Stuart, D.I]]
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[[Category: Rowlands, D J]]
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[[Category: Fry, E.E]]
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[[Category: Stuart, D I]]
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[[Category: Rao, Z]]
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[[Category: Zhou, D]]
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[[Category: Kotecha, A]]
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[[Category: Wang, X]]
[[Category: Wang, X]]
[[Category: Zhao, Y]]
[[Category: Zhao, Y]]
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[[Category: Rowlands, D.J]]
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[[Category: Zhou, D]]
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[[Category: Enterovirus 71]]
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[[Category: Ev71 receptor]]
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[[Category: Hand-foot-mouth disease]]
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[[Category: Scarb2]]
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[[Category: Virus]]

Revision as of 20:34, 2 December 2018

Structure of EV71 complexed with its receptor SCARB2

6i2k, resolution 3.40Å

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