6mtc

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'''Unreleased structure'''
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{{Large structure}}
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==Rabbit 80S ribosome with Z-site tRNA and IFRD2 (unrotated state)==
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<StructureSection load='6mtc' size='340' side='right' caption='[[6mtc]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6mtc]] is a 82 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MTC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MTC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=1MA:6-HYDRO-1-METHYLADENOSINE-5-MONOPHOSPHATE'>1MA</scene>, <scene name='pdbligand=2MG:2N-METHYLGUANOSINE-5-MONOPHOSPHATE'>2MG</scene>, <scene name='pdbligand=4AC:N(4)-ACETYLCYTIDINE-5-MONOPHOSPHATE'>4AC</scene>, <scene name='pdbligand=5MC:5-METHYLCYTIDINE-5-MONOPHOSPHATE'>5MC</scene>, <scene name='pdbligand=5MU:5-METHYLURIDINE+5-MONOPHOSPHATE'>5MU</scene>, <scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene>, <scene name='pdbligand=7MG:7N-METHYL-8-HYDROGUANOSINE-5-MONOPHOSPHATE'>7MG</scene>, <scene name='pdbligand=A2M:2-O-METHYLADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>A2M</scene>, <scene name='pdbligand=B8H:'>B8H</scene>, <scene name='pdbligand=B8K:'>B8K</scene>, <scene name='pdbligand=B8N:'>B8N</scene>, <scene name='pdbligand=B8Q:'>B8Q</scene>, <scene name='pdbligand=B8T:'>B8T</scene>, <scene name='pdbligand=B8W:'>B8W</scene>, <scene name='pdbligand=B9B:'>B9B</scene>, <scene name='pdbligand=B9H:'>B9H</scene>, <scene name='pdbligand=BGH:'>BGH</scene>, <scene name='pdbligand=E3C:'>E3C</scene>, <scene name='pdbligand=E6G:'>E6G</scene>, <scene name='pdbligand=E7G:'>E7G</scene>, <scene name='pdbligand=I4U:'>I4U</scene>, <scene name='pdbligand=M7A:'>M7A</scene>, <scene name='pdbligand=MA6:6N-DIMETHYLADENOSINE-5-MONOPHOSHATE'>MA6</scene>, <scene name='pdbligand=MHG:'>MHG</scene>, <scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene>, <scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene>, <scene name='pdbligand=P4U:'>P4U</scene>, <scene name='pdbligand=P7G:'>P7G</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=UR3:3-METHYLURIDINE-5-MONOPHOSHATE'>UR3</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mtc OCA], [http://pdbe.org/6mtc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mtc RCSB], [http://www.ebi.ac.uk/pdbsum/6mtc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mtc ProSAT]</span></td></tr>
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</table>
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{{Large structure}}
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== Function ==
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[[http://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The cellular levels and activities of ribosomes directly regulate gene expression during numerous physiological processes. The mechanisms that globally repress translation are incompletely understood. Here, we use electron cryomicroscopy to analyze inactive ribosomes isolated from mammalian reticulocytes, the penultimate stage of red blood cell differentiation. We identify two types of ribosomes that are translationally repressed by protein interactions. The first comprises ribosomes sequestered with elongation factor 2 (eEF2) by SERPINE mRNA binding protein 1 (SERBP1) occupying the ribosomal mRNA entrance channel. The second type are translationally repressed by a novel ribosome-binding protein, interferon-related developmental regulator 2 (IFRD2), which spans the P and E sites and inserts a C-terminal helix into the mRNA exit channel to preclude translation. IFRD2 binds ribosomes with a tRNA occupying a noncanonical binding site, the 'Z site', on the ribosome. These structures provide functional insights into how ribosomal interactions may suppress translation to regulate gene expression.
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The entry 6mtc is ON HOLD
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Structures of translationally inactive mammalian ribosomes.,Brown A, Baird MR, Yip MC, Murray J, Shao S Elife. 2018 Oct 24;7. pii: 40486. doi: 10.7554/eLife.40486. PMID:30355441<ref>PMID:30355441</ref>
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Authors: Brown, A., Baird, M.R., Yip, M.C.J., Murray, J., Shao, S.
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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Description: Rabbit 80S ribosome with Z-site tRNA and IFRD2 (unrotated state)
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<div class="pdbe-citations 6mtc" style="background-color:#fffaf0;"></div>
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[[Category: Unreleased Structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Oryctolagus cuniculus]]
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[[Category: Baird, M R]]
[[Category: Brown, A]]
[[Category: Brown, A]]
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[[Category: Yip, M.C.J]]
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[[Category: Murray, J]]
[[Category: Shao, S]]
[[Category: Shao, S]]
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[[Category: Baird, M.R]]
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[[Category: Yip, M C.J]]
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[[Category: Murray, J]]
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[[Category: Ribosome]]
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[[Category: Translation]]

Revision as of 21:12, 2 December 2018

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Rabbit 80S ribosome with Z-site tRNA and IFRD2 (unrotated state)

6mtc, resolution 3.40Å

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