3epv

From Proteopedia

(Difference between revisions)

Revision as of 21:44, 2 December 2018

X-ray Structure of the Metal-sensor CnrX in both the Apo- and Copper-bound Forms

Structural highlights

3epv is a 4 chain structure with sequence from Cupmc. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
NonStd Res:
Gene:	cnrR, cnrX, RMe0087, Rmet_6206 (CUPMC)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CNRR_RALME] CnrH alone is able to activate cnr expression, while both CnrY and CrnR (CnrX) are needed for nickel induction of CnrH (PubMed:10671463). Has been suggested (PubMed:10671464) to bind nickel.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Both the X-ray structures of the apo- and the copper-bound forms of the metal-sensor domain (residues 31-148) of CnrX from Cupriavidus metallidurans CH34 were obtained at 1.74A resolution from a selenomethionine derivative. This four-helix hooked-hairpin is the first structure of a metal-sensor in an ECF-type signaling pathway. The copper ion is bound in a type 2-like center with a 3N1O coordination in the equatorial plane and shows an unprecedented remote fifth axial ligand with Met93 contributing a weak S-Cu bond. The signal onset cannot be explained by conformational changes associated with CnrX metallation.

X-ray structure of the metal-sensor CnrX in both the apo- and copper-bound forms.,Pompidor G, Maillard AP, Girard E, Gambarelli S, Kahn R, Coves J FEBS Lett. 2008 Nov 26;582(28):3954-8. Epub 2008 Nov 4. PMID:18992246^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Pompidor G, Maillard AP, Girard E, Gambarelli S, Kahn R, Coves J. X-ray structure of the metal-sensor CnrX in both the apo- and copper-bound forms. FEBS Lett. 2008 Nov 26;582(28):3954-8. Epub 2008 Nov 4. PMID:18992246 doi:S0014-5793(08)00874-0

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3epv"

@@ Line 1: / Line 1: @@
 ==X-ray Structure of the Metal-sensor CnrX in both the Apo- and Copper-bound Forms==
 <StructureSection load='3epv' size='340' side='right' caption='[[3epv]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3epv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cupriavidus_metallidurans_ch34 Cupriavidus metallidurans ch34]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EPV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EPV FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3epv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cupmc Cupmc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EPV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EPV FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
 <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cnrR, cnrX, RMe0087, Rmet_6206 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=266264 Cupriavidus metallidurans CH34])</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cnrR, cnrX, RMe0087, Rmet_6206 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=266264 CUPMC])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3epv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3epv OCA], [http://pdbe.org/3epv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3epv RCSB], [http://www.ebi.ac.uk/pdbsum/3epv PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3epv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3epv OCA], [http://pdbe.org/3epv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3epv RCSB], [http://www.ebi.ac.uk/pdbsum/3epv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3epv ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 14: / Line 15: @@
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/3epv_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/3epv_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
@@ Line 33: / Line 34: @@
 __TOC__
 </StructureSection>
-[[Category: Cupriavidus metallidurans ch34]]
+[[Category: Cupmc]]
 [[Category: Coves, J]]
 [[Category: Gambarelli, S]]

3epv

From Proteopedia

Revision as of 21:44, 2 December 2018

X-ray Structure of the Metal-sensor CnrX in both the Apo- and Copper-bound Forms

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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