2z6o
From Proteopedia
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|PDB= 2z6o |SIZE=350|CAPTION= <scene name='initialview01'>2z6o</scene>, resolution 1.60Å | |PDB= 2z6o |SIZE=350|CAPTION= <scene name='initialview01'>2z6o</scene>, resolution 1.60Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene> | + | |LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span> |
|GENE= UFC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= UFC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2z6p|2Z6P]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z6o OCA], [http://www.ebi.ac.uk/pdbsum/2z6o PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2z6o RCSB]</span> | ||
}} | }} | ||
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[[Category: Tatsumi, K.]] | [[Category: Tatsumi, K.]] | ||
[[Category: Yamane, T.]] | [[Category: Yamane, T.]] | ||
| - | [[Category: MG]] | ||
[[Category: ligase]] | [[Category: ligase]] | ||
[[Category: polymorphism]] | [[Category: polymorphism]] | ||
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[[Category: ufm1]] | [[Category: ufm1]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:19:03 2008'' |
Revision as of 02:19, 31 March 2008
| |||||||
| , resolution 1.60Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | UFC1 (Homo sapiens) | ||||||
| Activity: | Ubiquitin--protein ligase, with EC number 6.3.2.19 | ||||||
| Related: | 2Z6P
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1
Overview
Ubiquitin and ubiquitin-like protein-conjugating enzymes play central roles in posttranslational modification processes. The ubiquitin-fold modifier 1 (Ufm1), one of a variety of ubiquitin-like modifiers, is covalently attached to target proteins via Uba5 and Ufm1-conjugating enzyme 1 (Ufc1), which are analogous to the E1 and E2 ubiquitylation enzymes. As Ufm1-related proteins are conserved in metazoa and plants, the Ufm1 system likely plays important roles in various multicellular organisms. Herein, we report the X-ray structure of human Ufc1 determined at 1.6 A resolution. The Ufc1 structure comprises a canonical E2 domain and an additional N-terminal domain. The Uba5 binding site on Ufc1 was assigned by structural comparison of Ufc1 and Ubc12 and related mutational analyses. In addition, we show that the N-terminal unique domain of Ufc1 contributes to thermal stability.
About this Structure
2Z6O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of Ufc1, the Ufm1-conjugating enzyme., Mizushima T, Tatsumi K, Ozaki Y, Kawakami T, Suzuki A, Ogasahara K, Komatsu M, Kominami E, Tanaka K, Yamane T, Biochem Biophys Res Commun. 2007 Nov 3;362(4):1079-84. Epub 2007 Aug 30. PMID:17825256
Page seeded by OCA on Mon Mar 31 05:19:03 2008
Categories: Homo sapiens | Single protein | Ubiquitin--protein ligase | Kawakami, T. | Komatsu, M. | Kominami, E. | Mizushima ,T. | Ogasahara, K. | Ozaki, Y. | Suzuki, A. | Tanaka, K. | Tatsumi, K. | Yamane, T. | Ligase | Polymorphism | Ubiquitin | Ubl | Ubl conjugation pathway | Ufc1 | Ufm1
