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Synaptotagmin

From Proteopedia

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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
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<StructureSection load='4npk' size='340' side='right' caption='Caption for this structure' scene=''>
== Function ==
== Function ==
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== Relevance ==
== Relevance ==
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'''Synaptotagmin-4''' is up-regulated by chronic depolarization and seizures. '''Synaptotagmin-1''' is promising biomarker to monitor dysfunction and degeneration in Alzheimer disease<ref>PMID:27716408</ref>.
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'''Synaptotagmin-4''' is up-regulated by chronic depolarization and seizures. '''Synaptotagmin-1''' is a promising biomarker to monitor dysfunction and degeneration in Alzheimer disease<ref>PMID:27716408</ref>.
== Structural highlights ==
== Structural highlights ==

Revision as of 09:00, 4 December 2018

Caption for this structure

Drag the structure with the mouse to rotate

3D structures of synaptotagmin

Updated on 04-December-2018



References

  1. ↑ Hu ZT, Chen MR, Ping Z, Dong YM, Zhang RY, Xu T, Wu ZX. Synaptotagmin IV regulates dense core vesicle (DCV) release in LbetaT2 cells. Biochem Biophys Res Commun. 2008 Jul 11;371(4):781-6. doi:, 10.1016/j.bbrc.2008.04.174. Epub 2008 May 9. PMID:18468511 doi:http://dx.doi.org/10.1016/j.bbrc.2008.04.174
  2. ↑ Xu J, Pang ZP, Shin OH, Sudhof TC. Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release. Nat Neurosci. 2009 Jun;12(6):759-66. doi: 10.1038/nn.2320. PMID:19412166 doi:http://dx.doi.org/10.1038/nn.2320
  3. ↑ Zhang X, Rizo J, Sudhof TC. Mechanism of phospholipid binding by the C2A-domain of synaptotagmin I. Biochemistry. 1998 Sep 8;37(36):12395-403. doi: 10.1021/bi9807512. PMID:9730811 doi:http://dx.doi.org/10.1021/bi9807512
  4. ↑ Chapman ER, Hanson PI, An S, Jahn R. Ca2+ regulates the interaction between synaptotagmin and syntaxin 1. J Biol Chem. 1995 Oct 6;270(40):23667-71. PMID:7559535
  5. ↑ Ohrfelt A, Brinkmalm A, Dumurgier J, Brinkmalm G, Hansson O, Zetterberg H, Bouaziz-Amar E, Hugon J, Paquet C, Blennow K. The pre-synaptic vesicle protein synaptotagmin is a novel biomarker for Alzheimer's disease. Alzheimers Res Ther. 2016 Oct 3;8(1):41. doi: 10.1186/s13195-016-0208-8. PMID:27716408 doi:http://dx.doi.org/10.1186/s13195-016-0208-8

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Michal Harel, Alexander Berchansky

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