2za3
From Proteopedia
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|SITE= <scene name='pdbsite=AC1:U5p+Binding+Site+For+Residue+A+500'>AC1</scene> and <scene name='pdbsite=AC2:U5p+Binding+Site+For+Residue+B+600'>AC2</scene> | |SITE= <scene name='pdbsite=AC1:U5p+Binding+Site+For+Residue+A+500'>AC1</scene> and <scene name='pdbsite=AC2:U5p+Binding+Site+For+Residue+B+600'>AC2</scene> | ||
|LIGAND= <scene name='pdbligand=U5P:URIDINE-5'-MONOPHOSPHATE'>U5P</scene> | |LIGAND= <scene name='pdbligand=U5P:URIDINE-5'-MONOPHOSPHATE'>U5P</scene> | ||
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2f84|2F84]], [[2za1|2ZA1]], [[2za2|2ZA2]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2za3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2za3 OCA], [http://www.ebi.ac.uk/pdbsum/2za3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2za3 RCSB]</span> | ||
}} | }} | ||
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[[Category: Inoue, T.]] | [[Category: Inoue, T.]] | ||
[[Category: Tokuoka, K.]] | [[Category: Tokuoka, K.]] | ||
| - | [[Category: U5P]] | ||
[[Category: lyase]] | [[Category: lyase]] | ||
[[Category: orotidine 5'-monophosphate decarboxylase]] | [[Category: orotidine 5'-monophosphate decarboxylase]] | ||
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[[Category: uridine 5'-monophosphate]] | [[Category: uridine 5'-monophosphate]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:19:51 2008'' |
Revision as of 02:19, 31 March 2008
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| , resolution 2.65Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | and | ||||||
| Ligands: | |||||||
| Activity: | Orotidine-5'-phosphate decarboxylase, with EC number 4.1.1.23 | ||||||
| Related: | 2F84, 2ZA1, 2ZA2
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of orotidine 5'-monophosphate decarboxylase complexed with uridine 5'-monophosphate from P.falciparum
Overview
Orotidine 5'-monophoshate decarboxylase (OMPDC) catalyses the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP). Here, we report the X-ray analysis of apo, substrate or product-complex forms of OMPDC from Plasmodium falciparum (PfOMPDC) at 2.7, 2.65 and 2.65 A, respectively. The structural analysis provides the substrate recognition mechanism with dynamic structural changes, as well as the rearrangement of the hydrogen bond array at the active site. The structural basis of substrate or product binding to PfOMPDC will help to uncover the decarboxylation mechanism and facilitate structure-based optimization of antimalarial drugs.
About this Structure
2ZA3 is a Single protein structure of sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.
Reference
Structural Basis for the Decarboxylation of Orotidine 5'-Monophosphate (OMP) by Plasmodium Falciparum OMP Decarboxylase., Tokuoka K, Kusakari Y, Krungkrai SR, Matsumura H, Kai Y, Krungkrai J, Horii T, Inoue T, J Biochem. 2008 Jan;143(1):69-78. Epub 2007 Nov 1. PMID:17981823
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