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| - | | + | REMOVED: The PDB entry 5k4k was removed. |
| - | ==Directed evolutionary changes in MBL super family - NDM-1 Round 10 crystal-4==
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| - | <StructureSection load='5k4k' size='340' side='right' caption='[[5k4k]], [[Resolution|resolution]] 1.76Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[5k4k]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K4K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K4K FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NPO:P-NITROPHENOL'>NPO</scene>, <scene name='pdbligand=SV7:PHENYLPHOSPHONIC+ACID'>SV7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jqj|5jqj]], [[5k4m|5k4m]], [[5k4n|5k4n]]</td></tr>
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| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k4k OCA], [http://pdbe.org/5k4k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k4k RCSB], [http://www.ebi.ac.uk/pdbsum/5k4k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k4k ProSAT]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Beta-lactamase]]
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| - | [[Category: Carr, P D]]
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| - | [[Category: Hong, N S]]
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| - | [[Category: Jackson, C J]]
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| - | [[Category: Directed evolution]]
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| - | [[Category: Hydrolase]]
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| - | [[Category: Mbl super family]]
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| - | [[Category: Ndm-1]]
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| - | [[Category: Phosphatase]]
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