5ywe

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'''Unreleased structure'''
 
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The entry 5ywe is ON HOLD until Paper Publication
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==Crystal structure of hematopoietic prostaglandin D synthase apo form==
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<StructureSection load='5ywe' size='340' side='right' caption='[[5ywe]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ywe]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YWE FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ywe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ywe OCA], [http://pdbe.org/5ywe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ywe RCSB], [http://www.ebi.ac.uk/pdbsum/5ywe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ywe ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/HPGDS_HUMAN HPGDS_HUMAN]] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Aritake, K]]
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[[Category: Furubayashi, N]]
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[[Category: Inaka, K]]
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[[Category: Kamo, M]]
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[[Category: Urade, Y]]
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[[Category: Prostaglandin d]]
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[[Category: Synthase]]
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[[Category: Transferase]]

Revision as of 06:29, 5 December 2018

Crystal structure of hematopoietic prostaglandin D synthase apo form

5ywe, resolution 1.68Å

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