5yx1
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of hematopoietic prostaglandin D synthase in complex with U004== | |
| - | + | <StructureSection load='5yx1' size='340' side='right' caption='[[5yx1]], [[Resolution|resolution]] 1.39Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5yx1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YX1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YX1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UX4:ethyl+4-[(8R)-3,8-dimethyl-4-oxo-4,6,7,8,9,10-hexahydrothieno[2,3 4,5]pyrimido[1,2-a]azepin-2-yl]carbamoylpiperazine-1-carboxylate'>UX4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yx1 OCA], [http://pdbe.org/5yx1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yx1 RCSB], [http://www.ebi.ac.uk/pdbsum/5yx1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yx1 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HPGDS_HUMAN HPGDS_HUMAN]] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Aritake, K]] | ||
| + | [[Category: Furubayashi, N]] | ||
| + | [[Category: Inaka, K]] | ||
| + | [[Category: Kamo, M]] | ||
| + | [[Category: Takaya, D]] | ||
| + | [[Category: Tanaka, A]] | ||
| + | [[Category: Urade, Y]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Prostaglandin]] | ||
| + | [[Category: Synthase]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 06:29, 5 December 2018
Crystal structure of hematopoietic prostaglandin D synthase in complex with U004
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