5yxk
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==High resolution crystal structure of Human B7-2 IgV domain in P21 space group== | |
| - | + | <StructureSection load='5yxk' size='340' side='right' caption='[[5yxk]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5yxk]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YXK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YXK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yxk OCA], [http://pdbe.org/5yxk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yxk RCSB], [http://www.ebi.ac.uk/pdbsum/5yxk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yxk ProSAT]</span></td></tr> | |
| - | [[ | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CD86_HUMAN CD86_HUMAN]] Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Lankipalli, S]] | [[Category: Lankipalli, S]] | ||
| - | [[Category: Ramagopal, U | + | [[Category: Ramagopal, U A]] |
| + | [[Category: B7-2]] | ||
| + | [[Category: Cd86]] | ||
| + | [[Category: Co-stimulatory molecule]] | ||
| + | [[Category: Ig super family]] | ||
| + | [[Category: Immune system]] | ||
Revision as of 06:30, 5 December 2018
High resolution crystal structure of Human B7-2 IgV domain in P21 space group
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