6ak3
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the endogenous agonist bound GPCR== | |
| - | + | <StructureSection load='6ak3' size='340' side='right' caption='[[6ak3]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ak3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AK3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P2E:(Z)-7-[(1R,2R,3R)-3-HYDROXY-2-[(E,3S)-3-HYDROXYOCT-1-ENYL]-5-OXO-CYCLOPENTYL]HEPT-5-ENOIC+ACID'>P2E</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ak3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ak3 OCA], [http://pdbe.org/6ak3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ak3 RCSB], [http://www.ebi.ac.uk/pdbsum/6ak3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ak3 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PE2R3_HUMAN PE2R3_HUMAN]] Receptor for prostaglandin E2 (PGE2) (PubMed:8307176, PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210). The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium (PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity).[UniProtKB:P30557]<ref>PMID:7883006</ref> <ref>PMID:7981210</ref> <ref>PMID:8117308</ref> <ref>PMID:8135729</ref> <ref>PMID:8307176</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Iwata, S]] | ||
| + | [[Category: Kobayashi, T]] | ||
| + | [[Category: Morimoto, K]] | ||
| + | [[Category: Suno, R]] | ||
| + | [[Category: Gpcr]] | ||
| + | [[Category: Lipid]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Prostanoid receptor]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 06:31, 5 December 2018
Crystal structure of the endogenous agonist bound GPCR
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