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6bqu

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'''Unreleased structure'''
 
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The entry 6bqu is ON HOLD until Paper Publication
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==Human GR (418-507) in complex with monomeric DNA binding site==
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<StructureSection load='6bqu' size='340' side='right' caption='[[6bqu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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Authors: Pufall, M.A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6bqu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BQU FirstGlance]. <br>
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Description: Human GR (418-507) in complex with monomeric DNA binding site
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bqu OCA], [http://pdbe.org/6bqu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bqu RCSB], [http://www.ebi.ac.uk/pdbsum/6bqu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bqu ProSAT]</span></td></tr>
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[[Category: Pufall, M.A]]
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[http://omim.org/entry/138040 138040]]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.<ref>PMID:21664385</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Pufall, M A]]
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[[Category: Dna binding protein]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Glucocorticoid receptor monomeric binding site]]

Revision as of 06:32, 5 December 2018

Human GR (418-507) in complex with monomeric DNA binding site

6bqu, resolution 2.50Å

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