6brb
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Novel non-antibody protein scaffold targeting CD40L== | |
| - | + | <StructureSection load='6brb' size='340' side='right' caption='[[6brb]], [[Resolution|resolution]] 2.82Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6brb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BRB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BRB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6brb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6brb OCA], [http://pdbe.org/6brb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6brb RCSB], [http://www.ebi.ac.uk/pdbsum/6brb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6brb ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/CD40L_HUMAN CD40L_HUMAN]] Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1) [MIM:[http://omim.org/entry/308230 308230]]; also known as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence.<ref>PMID:7678782</ref> <ref>PMID:7679206</ref> <ref>PMID:8094231</ref> <ref>PMID:7679801</ref> <ref>PMID:7717401</ref> <ref>PMID:7532185</ref> <ref>PMID:8889581</ref> <ref>PMID:8550833</ref> <ref>PMID:9150729</ref> <ref>PMID:9746782</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CD40L_HUMAN CD40L_HUMAN]] Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching.<ref>PMID:15193700</ref> Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.<ref>PMID:15193700</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Acqua, W F.Dall]] | ||
| + | [[Category: Baca, M]] | ||
[[Category: Grinberg, L]] | [[Category: Grinberg, L]] | ||
| - | [[Category: Dall'Acqua, W.F]] | ||
[[Category: Oganesyan, V]] | [[Category: Oganesyan, V]] | ||
[[Category: Thisted, T]] | [[Category: Thisted, T]] | ||
| - | [[Category: Baca, M]] | ||
[[Category: Wu, H]] | [[Category: Wu, H]] | ||
| + | [[Category: Structural protein-immune system complex]] | ||
| + | [[Category: Tn3 related]] | ||
| + | [[Category: Tnf ligand related]] | ||
Revision as of 06:32, 5 December 2018
Novel non-antibody protein scaffold targeting CD40L
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