6f3t
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the human TAF5-TAF6-TAF9 complex== | |
| - | + | <StructureSection load='6f3t' size='340' side='right' caption='[[6f3t]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6f3t]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F3T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F3T FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f3t OCA], [http://pdbe.org/6f3t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f3t RCSB], [http://www.ebi.ac.uk/pdbsum/6f3t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f3t ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TAF5_HUMAN TAF5_HUMAN]] TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not TAF7/TAFII55, also have been observed. [[http://www.uniprot.org/uniprot/TAF9_HUMAN TAF9_HUMAN]] Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.<ref>PMID:15899866</ref> [[http://www.uniprot.org/uniprot/TAF6_HUMAN TAF6_HUMAN]] TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Berger, I]] | ||
| + | [[Category: Haffke, M]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Taf]] | ||
| + | [[Category: Tbd-associated factor]] | ||
| + | [[Category: Tfiid]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 06:35, 5 December 2018
Crystal structure of the human TAF5-TAF6-TAF9 complex
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Categories: Berger, I | Haffke, M | Complex | Taf | Tbd-associated factor | Tfiid | Transcription
