3f96
From Proteopedia
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==Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by sarin== | ==Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by sarin== | ||
<StructureSection load='3f96' size='340' side='right' caption='[[3f96]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='3f96' size='340' side='right' caption='[[3f96]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3f96]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3f96]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F96 FirstGlance]. <br> |
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SGB:O-[(S)-METHYL(1-METHYLETHOXY)PHOSPHORYL]-L-SERINE'>SGB</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SGB:O-[(S)-METHYL(1-METHYLETHOXY)PHOSPHORYL]-L-SERINE'>SGB</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3d59|3d59]], [[3d5e|3d5e]], [[3f97|3f97]], [[3f98|3f98]], [[3f9c|3f9c]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3d59|3d59]], [[3d5e|3d5e]], [[3f97|3f97]], [[3f98|3f98]], [[3f9c|3f9c]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PLA2G7, PAFAH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PLA2G7, PAFAH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-alkyl-2-acetylglycerophosphocholine_esterase 1-alkyl-2-acetylglycerophosphocholine esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.47 3.1.1.47] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-alkyl-2-acetylglycerophosphocholine_esterase 1-alkyl-2-acetylglycerophosphocholine esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.47 3.1.1.47] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f96 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f96 RCSB], [http://www.ebi.ac.uk/pdbsum/3f96 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f96 OCA], [http://pdbe.org/3f96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f96 RCSB], [http://www.ebi.ac.uk/pdbsum/3f96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3f96 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/3f96_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/3f96_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f96 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3f96" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[ | + | *[[Phospholipase A2|Phospholipase A2]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: 1-alkyl-2-acetylglycerophosphocholine esterase]] | [[Category: 1-alkyl-2-acetylglycerophosphocholine esterase]] | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Bahnson, B J]] | [[Category: Bahnson, B J]] | ||
[[Category: Samanta, U]] | [[Category: Samanta, U]] | ||
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[[Category: Lp-pla2]] | [[Category: Lp-pla2]] | ||
[[Category: Plasma platelet-activating factor acetylhydrolase]] | [[Category: Plasma platelet-activating factor acetylhydrolase]] | ||
| + | [[Category: Polymorphism]] | ||
[[Category: Sarin]] | [[Category: Sarin]] | ||
[[Category: Secreted]] | [[Category: Secreted]] | ||
[[Category: Secreted protein]] | [[Category: Secreted protein]] | ||
Revision as of 07:33, 5 December 2018
Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by sarin
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Categories: 1-alkyl-2-acetylglycerophosphocholine esterase | Human | Bahnson, B J | Samanta, U | Alpha/beta-hydrolase-fold | Disease mutation | Glycoprotein | Group viia pla2 | Hydrolase | Ldl-bound | Lipid degradation | Lipoprotein associated phospholipase a2 | Lp-pla2 | Plasma platelet-activating factor acetylhydrolase | Polymorphism | Sarin | Secreted | Secreted protein
