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3b2u
From Proteopedia
(Difference between revisions)
| Line 4: | Line 4: | ||
|PDB= 3b2u |SIZE=350|CAPTION= <scene name='initialview01'>3b2u</scene>, resolution 2.580Å | |PDB= 3b2u |SIZE=350|CAPTION= <scene name='initialview01'>3b2u</scene>, resolution 2.580Å | ||
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name='pdbsite=FC8:So4+Binding+Site+For+Residue+K+214'>FC8</scene>, <scene name='pdbsite=FC9:So4+Binding+Site+For+Residue+E+1'>FC9</scene>, <scene name='pdbsite=GC1:So4+Binding+Site+For+Residue+X+214'>GC1</scene> and <scene name='pdbsite=GC2:So4+Binding+Site+For+Residue+V+1'>GC2</scene> | |SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Residue+A+3281'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Residue+A+3282'>AC2</scene>, <scene name='pdbsite=AC3:Bma+Binding+Site+For+Residue+A+3283'>AC3</scene>, <scene name='pdbsite=AC4:Man+Binding+Site+For+Residue+A+3284'>AC4</scene>, <scene name='pdbsite=AC5:Nag+Binding+Site+For+Residue+A+4201'>AC5</scene>, <scene name='pdbsite=AC6:Nag+Binding+Site+For+Residue+B+3281'>AC6</scene>, <scene name='pdbsite=AC7:Nag+Binding+Site+For+Residue+B+3282'>AC7</scene>, <scene name='pdbsite=AC8:Bma+Binding+Site+For+Residue+B+3283'>AC8</scene>, <scene name='pdbsite=AC9:Nag+Binding+Site+For+Residue+B+3371'>AC9</scene>, <scene 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name='pdbsite=DC9:Bma+Binding+Site+For+Residue+P+3283'>DC9</scene>, <scene name='pdbsite=EC1:Nag+Binding+Site+For+Residue+P+3371'>EC1</scene>, <scene name='pdbsite=EC2:Nag+Binding+Site+For+Residue+P+3891'>EC2</scene>, <scene name='pdbsite=EC3:Nag+Binding+Site+For+Residue+P+4201'>EC3</scene>, <scene name='pdbsite=EC4:Nag+Binding+Site+For+Residue+S+3281'>EC4</scene>, <scene name='pdbsite=EC5:Nag+Binding+Site+For+Residue+S+3282'>EC5</scene>, <scene name='pdbsite=EC6:Bma+Binding+Site+For+Residue+S+3283'>EC6</scene>, <scene name='pdbsite=EC7:Nag+Binding+Site+For+Residue+S+4201'>EC7</scene>, <scene name='pdbsite=EC8:Nag+Binding+Site+For+Residue+V+3281'>EC8</scene>, <scene name='pdbsite=EC9:Nag+Binding+Site+For+Residue+V+3282'>EC9</scene>, <scene name='pdbsite=FC1:Bma+Binding+Site+For+Residue+V+3283'>FC1</scene>, <scene name='pdbsite=FC2:Nag+Binding+Site+For+Residue+V+3891'>FC2</scene>, <scene name='pdbsite=FC3:Nag+Binding+Site+For+Residue+V+4201'>FC3</scene>, <scene name='pdbsite=FC4:So4+Binding+Site+For+Residue+O+214'>FC4</scene>, <scene name='pdbsite=FC5:So4+Binding+Site+For+Residue+A+1'>FC5</scene>, <scene name='pdbsite=FC6:So4+Binding+Site+For+Residue+G+214'>FC6</scene>, <scene name='pdbsite=FC7:So4+Binding+Site+For+Residue+U+214'>FC7</scene>, <scene name='pdbsite=FC8:So4+Binding+Site+For+Residue+K+214'>FC8</scene>, <scene name='pdbsite=FC9:So4+Binding+Site+For+Residue+E+1'>FC9</scene>, <scene name='pdbsite=GC1:So4+Binding+Site+For+Residue+X+214'>GC1</scene> and <scene name='pdbsite=GC2:So4+Binding+Site+For+Residue+V+1'>GC2</scene> | ||
| - | |LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | + | |LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span> |
|GENE= EGFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), EGFR, ERBB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= EGFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), EGFR, ERBB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[3b2v|3B2V]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b2u OCA], [http://www.ebi.ac.uk/pdbsum/3b2u PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3b2u RCSB]</span> | ||
}} | }} | ||
'''Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8''' | '''Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8''' | ||
| + | |||
| + | ==Disease== | ||
| + | Known disease associated with this structure: Adenocarcinoma of lung, response to tyrosine kinase inhibitor in OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]], Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]], Nonsmall cell lung cancer, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]] | ||
==About this Structure== | ==About this Structure== | ||
| Line 20: | Line 26: | ||
[[Category: Kussie, P.]] | [[Category: Kussie, P.]] | ||
[[Category: Li, S.]] | [[Category: Li, S.]] | ||
| - | [[Category: NAG]] | ||
| - | [[Category: SO4]] | ||
[[Category: alternative splicing]] | [[Category: alternative splicing]] | ||
[[Category: anti-oncogene]] | [[Category: anti-oncogene]] | ||
| + | [[Category: antigen:antibody complex]] | ||
| + | [[Category: antitumor]] | ||
[[Category: atp-binding]] | [[Category: atp-binding]] | ||
[[Category: cell cycle]] | [[Category: cell cycle]] | ||
| - | [[Category: cell surface receptor | + | [[Category: cell surface receptor]] |
[[Category: disease mutation]] | [[Category: disease mutation]] | ||
| + | [[Category: drug]] | ||
| + | [[Category: fab fragment]] | ||
| + | [[Category: glycoprotein]] | ||
[[Category: immune system/transferase complex]] | [[Category: immune system/transferase complex]] | ||
[[Category: kinase]] | [[Category: kinase]] | ||
| Line 40: | Line 49: | ||
[[Category: ubl conjugation]] | [[Category: ubl conjugation]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:22:31 2008'' |
Revision as of 02:22, 31 March 2008
| |||||||
| , resolution 2.580Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , and | ||||||
| Ligands: | , , , | ||||||
| Gene: | EGFR (Homo sapiens), EGFR, ERBB1 (Homo sapiens) | ||||||
| Activity: | Receptor protein-tyrosine kinase, with EC number 2.7.10.1 | ||||||
| Related: | 3B2V
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8
Disease
Known disease associated with this structure: Adenocarcinoma of lung, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, susceptibility to OMIM:[131550]
About this Structure
3B2U is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Page seeded by OCA on Mon Mar 31 05:22:31 2008
Categories: Homo sapiens | Protein complex | Receptor protein-tyrosine kinase | Ferguson, K M. | Kussie, P. | Li, S. | Alternative splicing | Anti-oncogene | Antigen:antibody complex | Antitumor | Atp-binding | Cell cycle | Cell surface receptor | Disease mutation | Drug | Fab fragment | Glycoprotein | Immune system/transferase complex | Kinase | Membrane | Nucleotide-binding | Phosphoprotein | Polymorphism | Secreted | Transferase | Transmembrane | Tyrosine-protein kinase | Ubl conjugation
