Vacuolar protein sorting-associated protein
From Proteopedia
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*'''Vps4''', '''Vps4A''', ''Vps4B'' complex catalyzes the disassembly of the ESCRT-III filament in an ATP-driven reaction. Vps4 proteins are required for centrosome and spindle maintenance<ref>PMID:20616062</ref>.<br /> | *'''Vps4''', '''Vps4A''', ''Vps4B'' complex catalyzes the disassembly of the ESCRT-III filament in an ATP-driven reaction. Vps4 proteins are required for centrosome and spindle maintenance<ref>PMID:20616062</ref>.<br /> | ||
*'''Vps9A''' activates Rab5 to GTP-bound form<ref>PMID:18055610</ref>.<br /> | *'''Vps9A''' activates Rab5 to GTP-bound form<ref>PMID:18055610</ref>.<br /> | ||
| - | *'''Vps15 may function as a G protein β subunit at the endosome | + | *'''Vps15''' may function as a G protein β subunit at the endosome <ref>PMID:19445518</ref>.<br /> |
| - | *'''Vps23''' is part of the ESCRT-I complex<br /> | + | *'''Vps23''' is involved in appropriate sorting of receptors within the yast endocytic pathway and is part of the ESCRT-I complex<ref>PMID:11134028</ref><br /> |
| - | *'''Vps25''' is part of the ESCRT-II complex<br /> | + | *'''Vps25''' is part of the ESCRT-II complex which contains two copies of the protein. It induces a conformational switch that converts inactive Vps20 into an active nucleator for Snf7 oligomerization<ref>PMID:20134403</ref>.<br /> |
| + | *'''Vps26A''' and '''Vps26B''' are part of the Vps29-Vps35-Vps26 retromer which mediates transport of transmembrane proteins from endosomes to the trans-Golgi network<ref>PMID:21920005</ref>.<br /> | ||
*'''Vps27''' is part of the ESCRT-0 complex<br /> | *'''Vps27''' is part of the ESCRT-0 complex<br /> | ||
*'''Vps36''' is part of the ESCRT-II complex<br /> | *'''Vps36''' is part of the ESCRT-II complex<br /> | ||
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== Relevance == | == Relevance == | ||
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| + | Vps25 in ''Drosophila'' possesses several properties of tumor repressor<ref>PMID:16256745</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 08:13, 11 December 2018
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3D structures of vacuolar protein sorting-associated protein
Updated on 11-December-2018
References
- ↑ Schmidt O, Teis D. The ESCRT machinery. Curr Biol. 2012 Feb 21;22(4):R116-20. doi: 10.1016/j.cub.2012.01.028. PMID:22361144 doi:http://dx.doi.org/10.1016/j.cub.2012.01.028
- ↑ Morita E, Colf LA, Karren MA, Sandrin V, Rodesch CK, Sundquist WI. Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):12889-94. doi:, 10.1073/pnas.1005938107. Epub 2010 Jun 29. PMID:20616062 doi:http://dx.doi.org/10.1073/pnas.1005938107
- ↑ Goh T, Uchida W, Arakawa S, Ito E, Dainobu T, Ebine K, Takeuchi M, Sato K, Ueda T, Nakano A. VPS9a, the common activator for two distinct types of Rab5 GTPases, is essential for the development of Arabidopsis thaliana. Plant Cell. 2007 Nov;19(11):3504-15. Epub 2007 Nov 30. PMID:18055610 doi:10.1105/tpc.107.053876
- ↑ Heenan EJ, Vanhooke JL, Temple BR, Betts L, Sondek JE, Dohlman HG. Structure and function of Vps15 in the endosomal G protein signaling pathway. Biochemistry. 2009 Jul 14;48(27):6390-401. PMID:19445518 doi:10.1021/bi900621w
- ↑ Bishop N, Woodman P. TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes. J Biol Chem. 2001 Apr 13;276(15):11735-42. Epub 2000 Dec 27. PMID:11134028 doi:http://dx.doi.org/10.1074/jbc.M009863200
- ↑ Teis D, Saksena S, Judson BL, Emr SD. ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation. EMBO J. 2010 Mar 3;29(5):871-83. doi: 10.1038/emboj.2009.408. Epub 2010 Feb 4. PMID:20134403 doi:http://dx.doi.org/10.1038/emboj.2009.408
- ↑ Bugarcic A, Zhe Y, Kerr MC, Griffin J, Collins BM, Teasdale RD. Vps26A and Vps26B subunits define distinct retromer complexes. Traffic. 2011 Dec;12(12):1759-73. doi: 10.1111/j.1600-0854.2011.01284.x. Epub, 2011 Oct 17. PMID:21920005 doi:http://dx.doi.org/10.1111/j.1600-0854.2011.01284.x
- ↑ Thompson BJ, Mathieu J, Sung HH, Loeser E, Rorth P, Cohen SM. Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila. Dev Cell. 2005 Nov;9(5):711-20. doi: 10.1016/j.devcel.2005.09.020. PMID:16256745 doi:http://dx.doi.org/10.1016/j.devcel.2005.09.020
