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3b8z

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|PDB= 3b8z |SIZE=350|CAPTION= <scene name='initialview01'>3b8z</scene>, resolution 1.400&Aring;
|PDB= 3b8z |SIZE=350|CAPTION= <scene name='initialview01'>3b8z</scene>, resolution 1.400&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=294:N-hydroxy-4-({4-[4-(trifluoromethyl)phenoxy]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxamide'>294</scene>
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|LIGAND= <scene name='pdbligand=294:N-HYDROXY-4-({4-[4-(TRIFLUOROMETHYL)PHENOXY]PHENYL}SULFONYL)TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE'>294</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= ADAMTS5, ADAMTS11, ADMP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= ADAMTS5, ADAMTS11, ADMP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
 +
|DOMAIN=
 +
|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b8z OCA], [http://www.ebi.ac.uk/pdbsum/3b8z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3b8z RCSB]</span>
}}
}}
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[[Category: Tortorella, M D.]]
[[Category: Tortorella, M D.]]
[[Category: Williams, J M.]]
[[Category: Williams, J M.]]
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[[Category: 294]]
 
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[[Category: CA]]
 
-
[[Category: ZN]]
 
[[Category: alpha/beta]]
[[Category: alpha/beta]]
[[Category: hydrolase]]
[[Category: hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:57:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:24:15 2008''

Revision as of 02:24, 31 March 2008

Image:3b8z.jpg


PDB ID 3b8z

Drag the structure with the mouse to rotate
, resolution 1.400Å
Ligands: , ,
Gene: ADAMTS5, ADAMTS11, ADMP2 (Homo sapiens)
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2)


Overview

Aggrecanase-2 (a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5)), a member of the ADAMTS protein family, is critically involved in arthritic diseases because of its direct role in cleaving the cartilage component aggrecan. The catalytic domain of aggrecanase-2 has been refolded, purified, and crystallized, and its three-dimensional structure determined to 1.4A resolution in the presence of an inhibitor. A high resolution structure of an ADAMTS/aggrecanase protein provides an opportunity for the development of therapeutics to treat osteoarthritis.

About this Structure

3B8Z is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)., Shieh HS, Mathis KJ, Williams JM, Hills RL, Wiese JF, Benson TE, Kiefer JR, Marino MH, Carroll JN, Leone JW, Malfait AM, Arner EC, Tortorella MD, Tomasselli A, J Biol Chem. 2008 Jan 18;283(3):1501-7. Epub 2007 Nov 8. PMID:17991750

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