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| - | ==Structures of N-terminal NDM motif of human BLM helicase==
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| - | <StructureSection load='5m1v' size='340' side='right' caption='[[5m1v]], [[Resolution|resolution]] 2.01Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[5m1v]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M1V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M1V FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </span></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m1v OCA], [http://pdbe.org/5m1v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m1v RCSB], [http://www.ebi.ac.uk/pdbsum/5m1v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m1v ProSAT]</span></td></tr>
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| - | </table>
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| - | == Disease ==
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| - | [[http://www.uniprot.org/uniprot/BLM_HUMAN BLM_HUMAN]] Bloom syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/BLM_HUMAN BLM_HUMAN]] Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE).<ref>PMID:9388193</ref> <ref>PMID:12019152</ref> <ref>PMID:21325134</ref> <ref>PMID:23509288</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: DNA helicase]]
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| - | [[Category: Ai, X]]
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| - | [[Category: Chen, W F]]
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| - | [[Category: Fan, S H]]
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| - | [[Category: Liu, N N]]
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| - | [[Category: Rety, S]]
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| - | [[Category: Shi, J]]
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| - | [[Category: Xi, X G]]
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| - | [[Category: Zhang, B]]
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| - | [[Category: Helicase dimerization alpha-helix motif]]
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| - | [[Category: Hydrolase]]
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Current revision
REMOVED: The PDB entry 5m1v was removed.
