5yk5
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==structure of the human Lamtor4-Lamtor5 complex== | |
| - | + | <StructureSection load='5yk5' size='340' side='right' caption='[[5yk5]], [[Resolution|resolution]] 2.03Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5yk5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YK5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YK5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yk5 OCA], [http://pdbe.org/5yk5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yk5 RCSB], [http://www.ebi.ac.uk/pdbsum/5yk5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yk5 ProSAT]</span></td></tr> | |
| - | [[ | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LTOR5_HUMAN LTOR5_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.<ref>PMID:12773388</ref> <ref>PMID:22980980</ref> [[http://www.uniprot.org/uniprot/LTOR4_HUMAN LTOR4_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.<ref>PMID:22980980</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Mu, Z]] | [[Category: Mu, Z]] | ||
[[Category: Wu, G]] | [[Category: Wu, G]] | ||
| + | [[Category: Cellular signal transduction pathway]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 06:38, 12 December 2018
structure of the human Lamtor4-Lamtor5 complex
| |||||||||||
