6cyr
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the UBE2A variant Q93E== | |
| - | + | <StructureSection load='6cyr' size='340' side='right' caption='[[6cyr]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6cyr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CYR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CYR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6cyo|6cyo]]</td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/E2_ubiquitin-conjugating_enzyme E2 ubiquitin-conjugating enzyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.23 2.3.2.23] </span></td></tr> |
| - | [[Category: Ranzani, A | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cyr OCA], [http://pdbe.org/6cyr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cyr RCSB], [http://www.ebi.ac.uk/pdbsum/6cyr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cyr ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/UBE2A_HUMAN UBE2A_HUMAN]] X-linked intellectual disability, Nascimento type. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/UBE2A_HUMAN UBE2A_HUMAN]] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.<ref>PMID:16337599</ref> <ref>PMID:20061386</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: E2 ubiquitin-conjugating enzyme]] | ||
| + | [[Category: Oliveira, J F.de]] | ||
| + | [[Category: Ranzani, A T]] | ||
| + | [[Category: Ligase]] | ||
| + | [[Category: Q93e variant]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Ubiquitin-conjungating enzyme e2 some]] | ||
Revision as of 06:43, 12 December 2018
Crystal structure of the UBE2A variant Q93E
| |||||||||||
