6ekz
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Direct-evolutioned unspecific peroxygenase from Agrocybe aegerita, in complex with propranolol== | |
| - | + | <StructureSection load='6ekz' size='340' side='right' caption='[[6ekz]], [[Resolution|resolution]] 1.08Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ekz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EKZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SNP:1-(ISOPROPYLAMINO)-3-(1-NAPHTHYLOXY)-2-PROPANOL'>SNP</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yor|2yor]], [[2yp1|2yp1]], [[5oxu|5oxu]], [[5oxt|5oxt]], [[5oy1|5oy1]], [[5oy2|5oy2]], [[6ekw|6ekw]], [[6ekx|6ekx]], [[6eky|6eky]]</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_peroxygenase Unspecific peroxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.2.1 1.11.2.1] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ekz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ekz OCA], [http://pdbe.org/6ekz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ekz RCSB], [http://www.ebi.ac.uk/pdbsum/6ekz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ekz ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/APO1_AGRAE APO1_AGRAE]] Aromatic peroxidase that oxidizes aryl alcohols into the corresponding aldehydes and then into the corresponding benzoic acids. Oxidizes toluene and naphthalene. Catalyzes the regioselective peroxide-dependent hydroxylation of propranolol and diclofenac to 5-hydroxypropranolol and 4'-hydroxydiclofenac. Catalyzes the regioselective peroxide-dependent hydroxylation of naphthalene to 1-naphthol or 2-naphthol via a naphthalene 1,2-oxide intermediate. Catalyzes the regioselective peroxide-dependent oxidation of pyridine to pyridine N-oxide. Halogenates monochlorodimedone and phenol. Oxidizes the sulfer-containing heterocycle dibenzothiophene to yield ring-hydroxylation products and to a lesser extent sulfoxidation products.<ref>PMID:15294788</ref> <ref>PMID:16253244</ref> <ref>PMID:17410351</ref> <ref>PMID:19022254</ref> <ref>PMID:19039585</ref> <ref>PMID:18815784</ref> <ref>PMID:19394224</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Unspecific peroxygenase]] | ||
| + | [[Category: Ramirez-Escudero, M]] | ||
| + | [[Category: Sanz-Aparicio, J]] | ||
| + | [[Category: Agrocybe aegerita]] | ||
| + | [[Category: Directed evolution]] | ||
| + | [[Category: Heme-thiolate peroxidase]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Padai]] | ||
| + | [[Category: Propranolol]] | ||
| + | [[Category: Upo]] | ||
Revision as of 06:46, 12 December 2018
Direct-evolutioned unspecific peroxygenase from Agrocybe aegerita, in complex with propranolol
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