6el4

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m (Protected "6el4" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6el4 is ON HOLD until Paper Publication
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==Direct-evolutioned unspecific peroxygenase from Agrocybe aegerita, in complex with veratryl alcohol==
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<StructureSection load='6el4' size='340' side='right' caption='[[6el4]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6el4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EL4 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=VOH:Veratryl+alcohol'>VOH</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yor|2yor]], [[2yp1|2yp1]], [[5oxu|5oxu]], [[5oxt|5oxt]], [[5oy1|5oy1]], [[5oy2|5oy2]], [[6ekw|6ekw]], [[6ekx|6ekx]], [[6eky|6eky]], [[6ekz|6ekz]], [[6el0|6el0]]</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_peroxygenase Unspecific peroxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.2.1 1.11.2.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6el4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6el4 OCA], [http://pdbe.org/6el4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6el4 RCSB], [http://www.ebi.ac.uk/pdbsum/6el4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6el4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/APO1_AGRAE APO1_AGRAE]] Aromatic peroxidase that oxidizes aryl alcohols into the corresponding aldehydes and then into the corresponding benzoic acids. Oxidizes toluene and naphthalene. Catalyzes the regioselective peroxide-dependent hydroxylation of propranolol and diclofenac to 5-hydroxypropranolol and 4'-hydroxydiclofenac. Catalyzes the regioselective peroxide-dependent hydroxylation of naphthalene to 1-naphthol or 2-naphthol via a naphthalene 1,2-oxide intermediate. Catalyzes the regioselective peroxide-dependent oxidation of pyridine to pyridine N-oxide. Halogenates monochlorodimedone and phenol. Oxidizes the sulfer-containing heterocycle dibenzothiophene to yield ring-hydroxylation products and to a lesser extent sulfoxidation products.<ref>PMID:15294788</ref> <ref>PMID:16253244</ref> <ref>PMID:17410351</ref> <ref>PMID:19022254</ref> <ref>PMID:19039585</ref> <ref>PMID:18815784</ref> <ref>PMID:19394224</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Unspecific peroxygenase]]
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[[Category: Ramirez-Escudero, M]]
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[[Category: Sanz-Aparicio, J]]
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[[Category: 4-dimethoxybenzyl alcohol]]
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[[Category: Agrocybe aegerita]]
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[[Category: Directed evolution]]
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[[Category: Heme-thiolate peroxidase]]
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[[Category: Oxidoreductase]]
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[[Category: Padai]]
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[[Category: Upo]]
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[[Category: Veratryl alcohol]]

Revision as of 06:46, 12 December 2018

Direct-evolutioned unspecific peroxygenase from Agrocybe aegerita, in complex with veratryl alcohol

6el4, resolution 1.53Å

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