6f5t
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of KDM4D with tetrazole ligand GF057== | |
| - | + | <StructureSection load='6f5t' size='340' side='right' caption='[[6f5t]], [[Resolution|resolution]] 1.58Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6f5t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F5T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F5T FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CQK:~{N}-oxidanyl-4-(2~{H}-1,2,3,4-tetrazol-5-yl)pyridine-2-carboxamide'>CQK</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f5t OCA], [http://pdbe.org/6f5t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f5t RCSB], [http://www.ebi.ac.uk/pdbsum/6f5t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f5t ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KDM4D_HUMAN KDM4D_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Heinemann, U]] | [[Category: Heinemann, U]] | ||
| - | [[Category: Malecki, P.H]] | ||
[[Category: Link, A]] | [[Category: Link, A]] | ||
| - | [[Category: Weiss, M | + | [[Category: Malecki, P H]] |
| + | [[Category: Weiss, M S]] | ||
| + | [[Category: Cancer]] | ||
| + | [[Category: Drug development]] | ||
| + | [[Category: Epigenetic]] | ||
| + | [[Category: Inhibitor design]] | ||
| + | [[Category: Kdm4d]] | ||
| + | [[Category: Ligand binding]] | ||
| + | [[Category: Ligand optimization]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Tetrazole]] | ||
Current revision
Crystal Structure of KDM4D with tetrazole ligand GF057
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