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6gnx
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the MAJIN-TERB2 heterotetrameric complex - selenomethionine derivative== | |
| - | + | <StructureSection load='6gnx' size='340' side='right' caption='[[6gnx]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6gnx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GNX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GNX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gnx OCA], [http://pdbe.org/6gnx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gnx RCSB], [http://www.ebi.ac.uk/pdbsum/6gnx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gnx ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MAJIN_HUMAN MAJIN_HUMAN]] Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane.[UniProtKB:Q9D992] [[http://www.uniprot.org/uniprot/TERB2_HUMAN TERB2_HUMAN]] Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA.[UniProtKB:Q9D494] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Davies, O R]] | ||
| + | [[Category: Dunce, J M]] | ||
| + | [[Category: Gurusaran, M]] | ||
| + | [[Category: Sen, L T]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Meiosis]] | ||
| + | [[Category: Structural protein]] | ||
| + | [[Category: Telomere]] | ||
Revision as of 06:50, 12 December 2018
Crystal structure of the MAJIN-TERB2 heterotetrameric complex - selenomethionine derivative
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Categories: Davies, O R | Dunce, J M | Gurusaran, M | Sen, L T | Complex | Meiosis | Structural protein | Telomere
