3bes

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|PDB= 3bes |SIZE=350|CAPTION= <scene name='initialview01'>3bes</scene>, resolution 2.2&Aring;
|PDB= 3bes |SIZE=350|CAPTION= <scene name='initialview01'>3bes</scene>, resolution 2.2&Aring;
|SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Residue+R+267'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Residue+R+268'>AC2</scene>, <scene name='pdbsite=AC3:Bma+Binding+Site+For+Residue+R+269'>AC3</scene>, <scene name='pdbsite=AC4:Nag+Binding+Site+For+Residue+R+270'>AC4</scene>, <scene name='pdbsite=AC5:Po4+Binding+Site+For+Residue+R+1'>AC5</scene>, <scene name='pdbsite=AC6:Po4+Binding+Site+For+Residue+L+139'>AC6</scene> and <scene name='pdbsite=AC7:Po4+Binding+Site+For+Residue+R+3'>AC7</scene>
|SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Residue+R+267'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Residue+R+268'>AC2</scene>, <scene name='pdbsite=AC3:Bma+Binding+Site+For+Residue+R+269'>AC3</scene>, <scene name='pdbsite=AC4:Nag+Binding+Site+For+Residue+R+270'>AC4</scene>, <scene name='pdbsite=AC5:Po4+Binding+Site+For+Residue+R+1'>AC5</scene>, <scene name='pdbsite=AC6:Po4+Binding+Site+For+Residue+L+139'>AC6</scene> and <scene name='pdbsite=AC7:Po4+Binding+Site+For+Residue+R+3'>AC7</scene>
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> and <scene name='pdbligand=PO4:PHOSPHATE ION'>PO4</scene>
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= IFNG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), C4R, IFNGR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12643 Ectromelia virus])
|GENE= IFNG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), C4R, IFNGR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12643 Ectromelia virus])
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|DOMAIN=
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bes OCA], [http://www.ebi.ac.uk/pdbsum/3bes PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bes RCSB]</span>
}}
}}
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==Overview==
==Overview==
Ectromelia virus (ECTV) encodes an IFN-gamma-binding protein (IFN-gammaBP(ECTV)) that disrupts IFN-gamma signaling and its ability to induce an antiviral state within cells. IFN-gammaBP(ECTV) is an important virulence factor that is highly conserved (&gt;90%) in all orthopoxviruses, including variola virus, the causative agent of smallpox. The 2.2-A crystal structure of the IFN-gammaBP(ECTV)/IFN-gamma complex reveals IFN-gammaBP(ECTV) consists of an IFN-gammaR1 ligand-binding domain and a 57-aa helix-turn-helix (HTH) motif that is structurally related to the transcription factor TFIIA. The HTH motif forms a tetramerization domain that results in an IFN-gammaBP(ECTV)/IFN-gamma complex containing four IFN-gammaBP(ECTV) chains and two IFN-gamma dimers. The structure, combined with biochemical and cell-based assays, demonstrates that IFN-gammaBP(ECTV) tetramers are required for efficient IFN-gamma antagonism.
Ectromelia virus (ECTV) encodes an IFN-gamma-binding protein (IFN-gammaBP(ECTV)) that disrupts IFN-gamma signaling and its ability to induce an antiviral state within cells. IFN-gammaBP(ECTV) is an important virulence factor that is highly conserved (&gt;90%) in all orthopoxviruses, including variola virus, the causative agent of smallpox. The 2.2-A crystal structure of the IFN-gammaBP(ECTV)/IFN-gamma complex reveals IFN-gammaBP(ECTV) consists of an IFN-gammaR1 ligand-binding domain and a 57-aa helix-turn-helix (HTH) motif that is structurally related to the transcription factor TFIIA. The HTH motif forms a tetramerization domain that results in an IFN-gammaBP(ECTV)/IFN-gamma complex containing four IFN-gammaBP(ECTV) chains and two IFN-gamma dimers. The structure, combined with biochemical and cell-based assays, demonstrates that IFN-gammaBP(ECTV) tetramers are required for efficient IFN-gamma antagonism.
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==Disease==
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Known disease associated with this structure: AIDS, rapid progression to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147570 147570]], Aplastic anemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147570 147570]], Interferon, immune, deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147570 147570]], Hepatitis C virus, resistance to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147570 147570]], TSC2 angiomyolipomas, renal, modifier of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147570 147570]], Tuberculosis, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147570 147570]]
==About this Structure==
==About this Structure==
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[[Category: Nuara, A A]]
[[Category: Nuara, A A]]
[[Category: Walter, M R.]]
[[Category: Walter, M R.]]
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[[Category: NAG]]
 
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[[Category: PO4]]
 
[[Category: antiviral defense]]
[[Category: antiviral defense]]
[[Category: cytokine]]
[[Category: cytokine]]
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[[Category: receptor]]
[[Category: receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:58:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:25:37 2008''

Revision as of 02:25, 31 March 2008

Image:3bes.jpg


PDB ID 3bes

Drag the structure with the mouse to rotate
, resolution 2.2Å
Sites: , , , , , and
Ligands: , ,
Gene: IFNG (Homo sapiens), C4R, IFNGR (Ectromelia virus)
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Structure of a Poxvirus ifngbp/ifng Complex


Contents

Overview

Ectromelia virus (ECTV) encodes an IFN-gamma-binding protein (IFN-gammaBP(ECTV)) that disrupts IFN-gamma signaling and its ability to induce an antiviral state within cells. IFN-gammaBP(ECTV) is an important virulence factor that is highly conserved (>90%) in all orthopoxviruses, including variola virus, the causative agent of smallpox. The 2.2-A crystal structure of the IFN-gammaBP(ECTV)/IFN-gamma complex reveals IFN-gammaBP(ECTV) consists of an IFN-gammaR1 ligand-binding domain and a 57-aa helix-turn-helix (HTH) motif that is structurally related to the transcription factor TFIIA. The HTH motif forms a tetramerization domain that results in an IFN-gammaBP(ECTV)/IFN-gamma complex containing four IFN-gammaBP(ECTV) chains and two IFN-gamma dimers. The structure, combined with biochemical and cell-based assays, demonstrates that IFN-gammaBP(ECTV) tetramers are required for efficient IFN-gamma antagonism.

Disease

Known disease associated with this structure: AIDS, rapid progression to OMIM:[147570], Aplastic anemia OMIM:[147570], Interferon, immune, deficiency OMIM:[147570], Hepatitis C virus, resistance to OMIM:[147570], TSC2 angiomyolipomas, renal, modifier of OMIM:[147570], Tuberculosis, susceptibility to OMIM:[147570]

About this Structure

3BES is a Protein complex structure of sequences from Ectromelia virus and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of IFN-gamma antagonism by an orthopoxvirus IFN-gamma-binding protein., Nuara AA, Walter LJ, Logsdon NJ, Yoon SI, Jones BC, Schriewer JM, Buller RM, Walter MR, Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1861-6. Epub 2008 Feb 5. PMID:18252829

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