6meo

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'''Unreleased structure'''
 
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The entry 6meo is ON HOLD until Paper Publication
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==Structural basis of coreceptor recognition by HIV-1 envelope spike==
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<StructureSection load='6meo' size='340' side='right' caption='[[6meo]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
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Authors: Shaik, M.M., Chen, B.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6meo]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MEO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MEO FirstGlance]. <br>
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Description: Structural basis of coreceptor recognition by HIV-1 envelope spike
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6meo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6meo OCA], [http://pdbe.org/6meo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6meo RCSB], [http://www.ebi.ac.uk/pdbsum/6meo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6meo ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN]] Genetic variation in CCR5 is associated with susceptibility to diabetes mellitus insulin-dependent type 22 (IDDM22) [MIM:[http://omim.org/entry/612522 612522]]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:19073967</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN]] Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.<ref>PMID:8639485</ref> <ref>PMID:8663314</ref> <ref>PMID:8699119</ref> <ref>PMID:8649511</ref> <ref>PMID:8649512</ref> <ref>PMID:11323418</ref> [[http://www.uniprot.org/uniprot/CD4_HUMAN CD4_HUMAN]] Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Chen, B]]
[[Category: Chen, B]]
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[[Category: Shaik, M.M]]
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[[Category: Shaik, M M]]
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[[Category: Hiv coreceptor]]
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[[Category: Membrane protein]]

Revision as of 06:56, 12 December 2018

Structural basis of coreceptor recognition by HIV-1 envelope spike

6meo, resolution 3.90Å

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