6n3h
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Kelch domain of the human NS1 binding protein== | |
| - | + | <StructureSection load='6n3h' size='340' side='right' caption='[[6n3h]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6n3h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N3H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N3H FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n3h OCA], [http://pdbe.org/6n3h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n3h RCSB], [http://www.ebi.ac.uk/pdbsum/6n3h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n3h ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NS1BP_HUMAN NS1BP_HUMAN]] Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription.<ref>PMID:16582008</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Chook, Y M]] | ||
| + | [[Category: Fontoura, B M.A]] | ||
| + | [[Category: Padavannil, A]] | ||
| + | [[Category: Shang, G]] | ||
| + | [[Category: Zhang, K]] | ||
| + | [[Category: Mrna export]] | ||
| + | [[Category: Mrna splicing]] | ||
| + | [[Category: Splicing]] | ||
Revision as of 06:59, 12 December 2018
Crystal structure of Kelch domain of the human NS1 binding protein
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