3-phosphoinositide-dependent protein kinase 1
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | '''3-phosphoinositide-dependent protein kinase 1''' (Pdk1) activates many other kinases. Pdk1 main effector is protein kinase B (Akt). <scene name='54/542348/Cv/ | + | '''3-phosphoinositide-dependent protein kinase 1''' (Pdk1) activates many other kinases. Pdk1 main effector is protein kinase B (Akt). <scene name='54/542348/Cv/6'>Serine (Ser241 in human) is the Pdk1 phosphorylated residue (PSer)</scene>. Pdk1 is important in signaling pathways activated by growth factors and hormones. It interacts with membrane phospholipids. <ref>PMID:15209375</ref> |
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | Pdk1 structure contains 2 domains: kinase (residues 71-359 in human) and PH (residues 459-550) in human). The PH (Plecksin Homology) domain interacts with phospholipids. | + | Pdk1 structure contains 2 domains: kinase (residues 71-359 in human) and PH (residues 459-550) in human). The PH (Plecksin Homology) domain interacts with phospholipids. The kinase domain (kd) contains 3 binding sites. These are for substrate-binding, ATP-binding and allosteric activator docking (PIF - [Pdk1-Interacting Fragment] -pocket). <scene name='54/542348/Cv/7'>Pyrazoloquinazoline inhibitor binding site</scene>. Water molecules shown as red spheres. |
</StructureSection> | </StructureSection> | ||
== 3D Structures of Pdk1== | == 3D Structures of Pdk1== | ||
Revision as of 11:39, 17 December 2018
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3D Structures of Pdk1
Updated on 17-December-2018
References
- ↑ Mora A, Komander D, van Aalten DM, Alessi DR. PDK1, the master regulator of AGC kinase signal transduction. Semin Cell Dev Biol. 2004 Apr;15(2):161-70. PMID:15209375
